Journal article

Publication year: 2017

Pages: 723-730

Journal: Artificial Cells, Nanomedicine, and Biotechnology

Volume number: 45

Issue number: 4

ISSN: 2169-1401

eISSN: 2169-141X

Open access status: Bronze

DOI Link: https://doi.org/10.1080/21691401.2017.1284858

Publisher: Taylor and Francis Group

Abstract: 
The aim of this study was to prove whether albumin-derived perfluorocarbon-based nanoparticles (capsules) can operate as a novel artificial oxygen carrier in a rat Langendorff-heart perfusion model. Hearts perfused with capsules showed increased left ventricular pressure and rate pressure product compared to hearts perfused with pure Krebs-Henseleit (KH)-buffer. The capsules prevented the myocardium from functional fail when in their absence a noxious ischemia was observed. Capsules did not change rheological properties of KH-buffer and could repeatedly reload with oxygen. This albumin-derived perfluorocarbon-based artificial oxygen carrier preserved the function of rat hearts due to the transport of oxygen in a satisfactory manner. Because of these positive results, the functionality of the applied capsules should be verified in living animals.

Harvard Citation style: Wrobeln, A., Schlueter, K., Linders, J., Zaehres, M., Mayer, C., Kirsch, M., et al. (2017) Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart, Artificial Cells, Nanomedicine, and Biotechnology, 45(4), pp. 723-730. https://doi.org/10.1080/21691401.2017.1284858

APA Citation style: Wrobeln, A., Schlueter, K., Linders, J., Zaehres, M., Mayer, C., Kirsch, M., & Ferenz, K. (2017). Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart. Artificial Cells, Nanomedicine, and Biotechnology. 45(4), 723-730. https://doi.org/10.1080/21691401.2017.1284858