Journalartikel

Jahr der Veröffentlichung: 2017

Seiten: 271-279

Zeitschrift: Clinical Research in Cardiology

Bandnummer: 106

Heftnummer: 4

ISSN: 1861-0684

eISSN: 1861-0692

DOI Link: https://doi.org/10.1007/s00392-016-1048-z

Verlag: Springer

Abstract: 

The objective was to investigate the acute mechanical effects of post-dilatation on bioresorbable scaffolds (BRS) as determined by optical coherence tomography (OCT).

Post-dilatation with high-pressure balloons is regarded as a key component of BRS implantation for treatment of coronary artery stenoses. However, the impact of post-dilatation on BRS in vivo has not been thoroughly investigated.

OCT was performed after the implantation procedure of 51 everolimus-eluting or novolimus-eluting polylactic acid-based BRS with (n = 27) or without non-compliant balloon post-dilatation (n = 24). The number of malapposed struts, strut fractures, edge dissections, residual in-scaffold area stenosis, and incomplete scaffold apposition area was analyzed over the complete length of each BRS with a spacing of 1 mm.

OCT revealed a significantly lower incomplete scaffold apposition area if post-dilatation was performed (0.16 +/- 0.49 mm(2) with post-dilatation vs. 2.65 +/- 2.78 mm(2) without post-dilatation, p < 0.001), as well as a significantly lower absolute number of malapposed struts (1 +/- 2 with post-dilatation vs. 13 +/- 13 without post-dilatation, p < 0.001). No significant differences regarding residual in-scaffold area stenosis, strut fracture, edge dissection, symmetry index, or eccentricity index were observed in patients with vs. without post-dilatation.

Post-dilatation of BRS with non-compliant balloons significantly reduces the number of malapposed struts and incomplete scaffold apposition area without inducing higher rates of edge dissection or strut fracture.

Harvard-Zitierstil: Blachutzik, F., Boeder, N., Wiebe, J., Mattesini, A., Doerr, O., Most, A., et al. (2017) Post-dilatation after implantation of bioresorbable everolimus- and novolimus-eluting scaffolds: an observational optical coherence tomography study of acute mechanical effects, Clinical Research in Cardiology, 106(4), pp. 271-279. https://doi.org/10.1007/s00392-016-1048-z

APA-Zitierstil: Blachutzik, F., Boeder, N., Wiebe, J., Mattesini, A., Doerr, O., Most, A., Bauer, T., Roether, J., Troebs, M., Schlundt, C., Achenbach, S., Hamm, C., & Nef, H. (2017). Post-dilatation after implantation of bioresorbable everolimus- and novolimus-eluting scaffolds: an observational optical coherence tomography study of acute mechanical effects. Clinical Research in Cardiology. 106(4), 271-279. https://doi.org/10.1007/s00392-016-1048-z