Journal article

Publication year: 2017

Pages: 304-310

Journal: Biomarkers

Volume number: 22

Issue number: 3-4

ISSN: 1354-750X

eISSN: 1366-5804

DOI Link: https://doi.org/10.1080/1354750X.2016.1252965

Publisher: Taylor and Francis Group

Abstract: 
Context: Troponin T upstream open reading frame peptide (TnTuORF) may be useful as a novel biomarker in acute cardiac syndromes.Objective: The study examined the early release kinetics of TnTuORF.Materials and methods: We analyzed the time course of the release of cardiac troponins I and T and TnTuORF in patients (n=31) with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH).Results: Fifteen minutes after TASH, the levels of both troponins increased significantly (cTnT median: 18ng/L versus 27ng/L; cTnI median: 15ng/L versus 25ng/L). TnTuORF showed no variation.Discussion: We observed a significantly greater increase in cTnI compared with cTnT.Conclusion: Our results demonstrate that troponin assays allow early detection of myocardial injury, whereas TnTuORF levels remain unchanged in this setting.

Harvard Citation style: Liebetrau, C., Gaede, L., Wolter, J., Homann, J., Meyer, A., Doerr, O., et al. (2017) Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction, Biomarkers, 22(3-4), pp. 304-310. https://doi.org/10.1080/1354750X.2016.1252965

APA Citation style: Liebetrau, C., Gaede, L., Wolter, J., Homann, J., Meyer, A., Doerr, O., Nef, H., Troidl, C., Hamm, C., Moellmann, H., Richards, A., & Pemberton, C. (2017). Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction. Biomarkers. 22(3-4), 304-310. https://doi.org/10.1080/1354750X.2016.1252965