Contribution in an anthology

Appeared in: HYPOXIA: TRANSLATION IN PROGRESS

Editor list: Roach, RC; Wagner, PD; Hackett, PH

Publication year: 2016

Pages: 169-185

Volume number: 903

ISSN: 0065-2598

ISBN: 978-1-4899-7676-5

eISSN: 2214-8019

eISBN: 978-1-4899-7678-9

DOI Link: https://doi.org/10.1007/978-1-4899-7678-9_12

Title of series: Advances in Experimental Medicine and Biology

Abstract: 
Tumors serve as a prototype system to study the role of the hypoxic microenvironment and gain insight in the regulation oxygen homeostasis. A series of biochemical and cell biological studies have significantly extended our knowledge of how tumor cells activate key regulatory mechanisms of oxygen homeostasis not only to adapt to the hostile tumor microenvironment but also to acquire a more aggressive tumor phenotype. Reduced oxygen levels and tumor-specific genetic alterations synergistically drive tumor progression by activating a key transcriptional system, the hypoxia inducible factors (HIFs). HIFs trigger a set of adaptive responses commonly associated with tumor malignancy including tumor angiogenesis, a shift in metabolism, proliferation, invasion, and metastasis. We and others could demonstrate that cancer stem cells are controlled by HIFs within a hypoxic niche, establishing an intriguing link between the well known function of hypoxia in tumor growth and stem cell biology. Additionally, HIF activation potentially conveys resistance to current tumor therapies including the evasive resistance phenotype observed after anti-angiogenic treatment. Together, these findings provide strong evidence that activation of the HIF system is a decisive step in cancer progression that critically shapes therapy response and clinical outcome. Recent insight into the precise mechanisms of oxygen sensing and signalling has offered new promising and potentially selective strategies to counteract this crucial pathway.

Harvard Citation style: Garvalov, B. and Acker, T. (2016) Implications of Oxygen Homeostasis for Tumor Biology and Treatment, in Roach, R., Wagner, P. and Hackett, P. (eds.) HYPOXIA: TRANSLATION IN PROGRESS. SPRINGER, pp. 169-185. https://doi.org/10.1007/978-1-4899-7678-9_12

APA Citation style: Garvalov, B., & Acker, T. (2016). Implications of Oxygen Homeostasis for Tumor Biology and Treatment. In Roach, R., Wagner, P., & Hackett, P. (Eds.), HYPOXIA: TRANSLATION IN PROGRESS (pp. 169-185). SPRINGER. https://doi.org/10.1007/978-1-4899-7678-9_12