Journal article
Authors list: Ripperger, Tim; Bielack, Stefan S.; Borkhardt, Arndt; Brecht, Ines B.; Burkhardt, Birgit; Calaminus, Gabriele; Debatin, Klaus-Michael; Deubzer, Hedwig; Dirksen, Uta; Eckert, Cornelia; Eggert, Angelika; Erlacher, Miriam; Fleischhack, Gudrun; Fruehwald, Michael C.; Gnekow, Astrid; Goehring, Gudrun; Graf, Norbert; Hanenberg, Helmut; Hauer, Julia; Hero, Barbara; Hettmer, Simone; von Hoff, Katja; Horstmann, Martin; Hoyer, Juliane; Illig, Thomas; Kaatsch, Peter; Kappler, Roland; Kerl, Kornelius; Klingebiel, Thomas; Kontny, Udo; Kordes, Uwe; Koerholz, Dieter; Koscielniak, Ewa; Kramm, Christof M.; Kuhlen, Michaela; Kulozik, Andreas E.; Lamottke, Britta; Leuschner, Ivo; Lohmann, Dietmar R.; Meinhardt, Andrea; Metzler, Markus; Meyer, Lder H.; Moser, Olga; Nathrath, Michaela; Niemeyer, Charlotte M.; Nustede, Rainer; Pajtler, Kristian W.; Paret, Claudia; Rasche, Mareike; Reinhardt, Dirk; Riess, Olaf; Russo, Alexandra; Rutkowski, Stefan; Schlegelberger, Brigitte; Schneider, Dominik; Schneppenheim, Reinhard; Schrappe, Martin; Schroeder, Christopher; von Schweinitz, Dietrich; Simon, Thorsten; Sparber-Sauer, Monika; Spix, Claudia; Stanulla, Martin; Steinemann, Doris; Strahm, Brigitte; Temming, Petra; Thomay, Kathrin; von Bueren, Andre O.; Vorwerk, Peter; Witt, Olaf; Wlodarski, Marcin; Woessmann, Willy; Zenker, Martin; Zimmermann, Stefanie; Pfister, Stefan M.; Kratz, Christian P.
Publication year: 2017
Pages: 1017-1037
Journal: The American Journal of Medical Genetics - Part A
Volume number: 173
Issue number: 4
ISSN: 1552-4825
eISSN: 1552-4833
DOI Link: https://doi.org/10.1002/ajmg.a.38142
Publisher: Wiley
Abstract:
Heritable predisposition is an important cause of cancer in children and adolescents. Although a large number of cancer predisposition genes and their associated syndromes and malignancies have already been described, it appears likely that there are more pediatric cancer patients in whom heritable cancer predisposition syndromes have yet to be recognized. In a consensus meeting in the beginning of 2016, we convened experts in Human Genetics and Pediatric Hematology/Oncology to review the available data, to categorize the large amount of information, and to develop recommendations regarding when a cancer predisposition syndrome should be suspected in a young oncology patient. This review summarizes the current knowledge of cancer predisposition syndromes in pediatric oncology and provides essential information on clinical situations in which a childhood cancer predisposition syndrome should be suspected.
Citation Styles
Harvard Citation style: Ripperger, T., Bielack, S., Borkhardt, A., Brecht, I., Burkhardt, B., Calaminus, G., et al. (2017) Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology, The American Journal of Medical Genetics - Part A, 173(4), pp. 1017-1037. https://doi.org/10.1002/ajmg.a.38142
APA Citation style: Ripperger, T., Bielack, S., Borkhardt, A., Brecht, I., Burkhardt, B., Calaminus, G., Debatin, K., Deubzer, H., Dirksen, U., Eckert, C., Eggert, A., Erlacher, M., Fleischhack, G., Fruehwald, M., Gnekow, A., Goehring, G., Graf, N., Hanenberg, H., Hauer, J., ...Kratz, C. (2017). Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology. The American Journal of Medical Genetics - Part A. 173(4), 1017-1037. https://doi.org/10.1002/ajmg.a.38142
Keywords
ACUTE LYMPHOBLASTIC-LEUKEMIA; BIALLELIC FANCD1/BRCA2 MUTATIONS; FAMILIAL ADENOMATOUS POLYPOSIS; genetic cancer predisposition; genetic predisposition testing; genetic screening; germline mutation; hereditary cancer syndrome; JUVENILE MYELOMONOCYTIC LEUKEMIA; LI-FRAUMENI SYNDROME; TUBEROUS SCLEROSIS COMPLEX; TUMOR-SUPPRESSOR GENE
