Journalartikel
Autorenliste: Kampers, Johanna; Orjuela-Grimm, Manuela; Schober, Tilmann; Schulz, Thomas F.; Stiefel, Martina; Klein, Christoph; Koerholz, Dieter; Mauz-Koerholz, Christine; Kreipe, Hans; Beier, Rita; Maecker-Kolhoff, Britta
Jahr der Veröffentlichung: 2017
Seiten: 633-638
Zeitschrift: Leukemia & Lymphoma
Bandnummer: 58
Heftnummer: 3
ISSN: 1042-8194
eISSN: 1029-2403
DOI Link: https://doi.org/10.1080/10428194.2016.1205742
Verlag: Taylor and Francis Group
Abstract:
Post-transplant lymphoproliferative disease (PTLD) is a severe complication after solid organ transplantation (SOT). Classical Hodgkin lymphoma-type (HL-) PTLD is a rare subtype, and systematic data on treatment and prognosis are lacking. We report on 17 pediatric patients with classical HL-PTLD. HL-PTLD developed late at a median of 8.1 years after SOT. It was commonly EBV-positive (16/17) and expressed both CD30 (all tumors) and CD20 (8/17 tumors). Patients were treated with chemotherapy(+/-) involved field radiotherapy (IF-RT) according to the respective GPOH-HD protocol tailored by stage and LDH. Overall survival at 2 and 5 years was 86% with 81% of patients surviving event-free. Six patients had additional rituximab treatment; in two it was given as upfront monotherapy and in four was given concurrently with their chemotherapy. Rituximab monotherapy did not lead to long-term remission. In conclusion, treatment of HL-PTLD with classical HL chemotherapy is effective and tolerable. New treatment modalities such as CD30-targeted or EBV-specific agents may diminish toxicity.
Zitierstile
Harvard-Zitierstil: Kampers, J., Orjuela-Grimm, M., Schober, T., Schulz, T., Stiefel, M., Klein, C., et al. (2017) Classical Hodgkin lymphoma-type PTLD after solid organ transplantation in children: a report on 17 patients treated according to subsequent GPOH-HD treatment schedules, Leukemia & Lymphoma, 58(3), pp. 633-638. https://doi.org/10.1080/10428194.2016.1205742
APA-Zitierstil: Kampers, J., Orjuela-Grimm, M., Schober, T., Schulz, T., Stiefel, M., Klein, C., Koerholz, D., Mauz-Koerholz, C., Kreipe, H., Beier, R., & Maecker-Kolhoff, B. (2017). Classical Hodgkin lymphoma-type PTLD after solid organ transplantation in children: a report on 17 patients treated according to subsequent GPOH-HD treatment schedules. Leukemia & Lymphoma. 58(3), 633-638. https://doi.org/10.1080/10428194.2016.1205742
Schlagwörter
EPSTEIN-BARR-VIRUS; Hodgkin lymphoma; Pediatric; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER; PTLD; solid organ transplantation
