Journal article
Authors list: Groeger, Sabine; Howaldt, H. P.; Raifer, H.; Gattenloehner, S.; Chakraborty, T.; Meyle, J.
Publication year: 2017
Pages: 99-110
Journal: Pathology & Oncology Research
Volume number: 23
Issue number: 1
ISSN: 1219-4956
eISSN: 1532-2807
DOI Link: https://doi.org/10.1007/s12253-016-0100-7
Publisher: Frontiers Media
Abstract:
B7-H1 and B7-DC ligands are members of the B7 family with important regulatory functions in cell-mediated immune response. Both receptors are ligands of the programmed death receptor PD-1. B7-H1 expression has been detected in the majority of human carcinomas in vivo. B7-H1 mediated signals are able to negatively regulate activated T cell functions and survival, and enable tumor cells to overcome host response. The aim of this study was to investigate the expression of B7-H1 and B7-DC proteins in oral squamous cell carcinomas (OSCC) in vivo. Tissues from 15 samples were cryo-sected and following histological routine staining (HE), incubated with antibodies against human B7-H1 and B7-DC. Immuno-staining of pan-cytokeratin was performed to ascertain the epithelial origin of the tissue and CK 19 to demonstrate the proliferating stage. Confocal laser scanning microscopy confirmed the presence of both B7-H1 and B7-DC in all 15 OSCC. The B7-H1 and B7-DC staining was located in areas of the tissue that were identified as cancerous lesions in the previously stained HE sections before. Staining with Pan-CK and CK19 provided evidence for the epithelial origin and the proliferating stage of the tissue. The in vivo expression of the B7-H1 and B7-DC receptors in oral squamous cell carcinomas suggest that general mechanisms for immune evasion of tumors are also found in OSCC.
Citation Styles
Harvard Citation style: Groeger, S., Howaldt, H., Raifer, H., Gattenloehner, S., Chakraborty, T. and Meyle, J. (2017) Oral Squamous Carcinoma Cells Express B7-H1 and B7-DC Receptors in Vivo, Pathology & Oncology Research, 23(1), pp. 99-110. https://doi.org/10.1007/s12253-016-0100-7
APA Citation style: Groeger, S., Howaldt, H., Raifer, H., Gattenloehner, S., Chakraborty, T., & Meyle, J. (2017). Oral Squamous Carcinoma Cells Express B7-H1 and B7-DC Receptors in Vivo. Pathology & Oncology Research. 23(1), 99-110. https://doi.org/10.1007/s12253-016-0100-7
Keywords
B7-Dc; B7 FAMILY; B7-H1; B7-RELATED MOLECULE; CANCER-CELLS; GR-1(+) MYELOID CELLS; HUMAN ENDOTHELIAL-CELLS; immune evasion; IMMUNOLOGICAL SELF-TOLERANCE; Oral squamous cell carcinomas; POTENTIAL MECHANISM; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES
