Journal article
Authors list: El Agha, Elie; Moiseenko, Alena; Kheirollahi, Vahid; De langhe, Stijn; Crnkovic, Slaven; Kwapiszewska, Grazyna; Kosanovic, Djuro; Schwind, Felix; Schermuly, Ralph T.; Henneke, Ingrid; MacKenzie, BreAnne; Quantius, Jennifer; Herold, Susanne; Ntokou, Aglaia; Ahlbrecht, Katrin; Morty, Rory E.; Guenther, Andreas; Seeger, Werner; Bellusci, Saverio
Publication year: 2017
Pages: 261-26+
Journal: Cell Stem Cell
Volume number: 20
Issue number: 2
ISSN: 1934-5909
eISSN: 1875-9777
Open access status: Green
DOI Link: https://doi.org/10.1016/j.stem.2016.10.004
Publisher: Elsevier
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with unknown etiology. Due to a lack of effective treatment, IPF is associated with a high mortality rate. The hallmark feature of this disease is the accumulation of activated myofibroblasts that excessively deposit extracellular matrix proteins, thus compromising lung architecture and function and hindering gas exchange. Here we investigated the origin of activated myofibroblasts and the molecular mechanisms governing fibrosis formation and resolution. Genetic engineering in mice enables the time-controlled labeling and monitoring of lipogenic or myogenic populations of lung fibroblasts during fibrosis formation and resolution. Our data demonstrate a lipogenic-to-myogenic switch in fibroblastic phenotype during fibrosis formation. Conversely, we observed a myogenic-to-lipogenic switch during fibrosis resolution. Analysis of human lung tissues and primary human lung fibroblasts indicates that this fate switching is involved in IPF pathogenesis, opening potential therapeutic avenues to treat patients.
Citation Styles
Harvard Citation style: El Agha, E., Moiseenko, A., Kheirollahi, V., De langhe, S., Crnkovic, S., Kwapiszewska, G., et al. (2017) Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis, Cell Stem Cell, 20(2), pp. 261-26+. https://doi.org/10.1016/j.stem.2016.10.004
APA Citation style: El Agha, E., Moiseenko, A., Kheirollahi, V., De langhe, S., Crnkovic, S., Kwapiszewska, G., Kosanovic, D., Schwind, F., Schermuly, R., Henneke, I., MacKenzie, B., Quantius, J., Herold, S., Ntokou, A., Ahlbrecht, K., Morty, R., Guenther, A., Seeger, W., & Bellusci, S. (2017). Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis. Cell Stem Cell. 20(2), 261-26+. https://doi.org/10.1016/j.stem.2016.10.004
Keywords
FIBROBLAST-GROWTH-FACTOR-10; FIBROCYTES; LIPOFIBROBLAST; MYOFIBROBLAST; PULMONARY-FIBROSIS; SMOOTH-MUSCLE-CELLS
