Journal article
Authors list: Lukaschek, Karoline; von Schacky, Clemens; Kruse, Johannes; Ladwig, Karl-Heinz
Publication year: 2016
Pages: 236-245
Journal: Dementia and Geriatric Cognitive Disorders
Volume number: 42
Issue number: 3-4
ISSN: 1420-8008
eISSN: 1421-9824
Open access status: Green
DOI Link: https://doi.org/10.1159/000448805
Publisher: Karger Publishers
Abstract:
Background: Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults. Methods: Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age: 77.6, SD +/- 6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoic acid (omega-3 index) were measured in erythrocytes as a percentage of total fatty acids. The categories low (<5.7), intermediate (5.7-6.8), and high (>6.8) levels of the omega-3 index were built using tertiles. The association between cognitive status and omega-3 levels was assessed by logistic regression analyses with adjustments for important concurrent risk factors of cognitive decline. Results: In the sex-and age-adjusted model (model 1), subjects with a low omega-3 index were at a significantly higher risk for cognitive impairment (OR: 1.77, 95% CI: 1.15-2.73, p = 0.009). This association remained stable after further adjusting for educational level (model 2; OR: 1.75, 95% CI: 1.13-2.71, p = 0.01) and metabolic risk factors (model 3; OR: 1.77, 95% CI: 1.14-2.75, p = 0.01). After further controlling for affective disorders (model 4), the association did not attenuate (OR: 1.77, 95% CI: 1.14-2.76, p = 0.01). Conclusion: A robust association was found between low omega-3 levels and cognitive impairment in an elderly population. Further research is needed to understand the link between omega-3 PUFA and cognitive functioning. (C) 2016 S. Karger AG, Basel
Citation Styles
Harvard Citation style: Lukaschek, K., von Schacky, C., Kruse, J. and Ladwig, K. (2016) Cognitive Impairment Is Associated with a Low Omega-3 Index in the Elderly: Results from the KORA-Age Study, Dementia and Geriatric Cognitive Disorders, 42(3-4), pp. 236-245. https://doi.org/10.1159/000448805
APA Citation style: Lukaschek, K., von Schacky, C., Kruse, J., & Ladwig, K. (2016). Cognitive Impairment Is Associated with a Low Omega-3 Index in the Elderly: Results from the KORA-Age Study. Dementia and Geriatric Cognitive Disorders. 42(3-4), 236-245. https://doi.org/10.1159/000448805
Keywords
DIETARY-SUPPLEMENTS; elderly population; LONG-CHAIN OMEGA-3-FATTY-ACIDS; N-3 FATTY-ACIDS; OLDER PERSONS; Omega-3 index; Population-based study; TELEPHONE INTERVIEW
