Journalartikel

Jahr der Veröffentlichung: 2016

Seiten: 73552-73557

Zeitschrift: Oncotarget

Bandnummer: 7

Heftnummer: 45

eISSN: 1949-2553

Open Access Status: Gold

DOI Link: https://doi.org/10.18632/oncotarget.12429

Verlag: Impact Journals

Abstract: 

An exact classification of precancerous stages of colorectal polyps might improve therapy and patients' outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from patients with cancerous and non-cancerous colorectal adenomas. A reproducible staining procedure for histologic MMP-13 analysis in routinely fixed colorectal biopsy specimens has been established. A newly adopted immunoreactive scoring system for MMP-13 was demonstrated as reliable readout.

The strength of the association between pathologic stage and immunoreactive MMP-13 scoring emphasizes its eligibility for diagnosis in precancerous colorectal lesions.

Harvard-Zitierstil: Wernicke, A., Churin, Y., Sheridan, D., Windhorst, A., Tschuschner, A., Gattenloehner, S., et al. (2016) Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions, Oncotarget, 7(45), pp. 73552-73557. https://doi.org/10.18632/oncotarget.12429

APA-Zitierstil: Wernicke, A., Churin, Y., Sheridan, D., Windhorst, A., Tschuschner, A., Gattenloehner, S., Roderfeld, M., & Roeb, E. (2016). Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions. Oncotarget. 7(45), 73552-73557. https://doi.org/10.18632/oncotarget.12429