Journalartikel

Jahr der Veröffentlichung: 2016

Seiten: 46-58

Zeitschrift: Reproductive Toxicology

Bandnummer: 65

ISSN: 0890-6238

DOI Link: https://doi.org/10.1016/j.reprotox.2016.06.016

Verlag: Elsevier

Abstract: 
Man-made magnetic fields (MFs) may exert adverse effects on mammalian embryonic development. Herein, we analysed the effect of 10 mT 50 Hz sinusoidal (AC) or static (DC) MFs versus 1 mT MFs on embryonic development of mice. Exposure for 20 days during gestation to 10 mT MFs increased resorptions and dead fetuses, decreased crown-rump length and fresh weight, reduced blood vessel differentiation and caused histological changes, accompanied with diminished vascular endothelial growth factor (VEGF) protein expression in several organs. In embryonic stem (ES) cell-derived embryoid bodies exposure towards 10 mT MFs increased reactive oxygen species (ROS), decreased vascular marker as well as VEGF expression and enhanced apoptosis. In conclusion, our combined data from in vivo and in vitro experiments identified VEGF as an important mediator during embryonic development that can be influenced by high strength MFs, which in consequence leads to severe abnormalities in fetus organs and blood vessel formation. (C) 2016 Elsevier Inc. All rights reserved.

Harvard-Zitierstil: Bekhite, M., Finkensieper, A., Abou-Zaid, F., El-Shourbagy, I., El-Fiky, N., Omar, K., et al. (2016) Differential effects of high and low strength magnetic fields on mouse embryonic development and vasculogenesis of embryonic stem cells, Reproductive Toxicology, 65, pp. 46-58. https://doi.org/10.1016/j.reprotox.2016.06.016

APA-Zitierstil: Bekhite, M., Finkensieper, A., Abou-Zaid, F., El-Shourbagy, I., El-Fiky, N., Omar, K., Sauer, H., & Wartenberg, M. (2016). Differential effects of high and low strength magnetic fields on mouse embryonic development and vasculogenesis of embryonic stem cells. Reproductive Toxicology. 65, 46-58. https://doi.org/10.1016/j.reprotox.2016.06.016