Journal article

Publication year: 2016

Pages: 2018-2027

Journal: European Journal of Immunology

Volume number: 46

Issue number: 8

ISSN: 0014-2980

eISSN: 1521-4141

Open access status: Green

DOI Link: https://doi.org/10.1002/eji.201646319

Publisher: Wiley

Abstract: 
Regulatory mechanisms initiated by allergen-specific immunotherapy are mainly attributed to T cell derived IL-10. However, it has not been shown that T cell derived IL-10 is required for successful tolerance induction (TI). Here, we analyze cellular sources and the functional relevance of cell type specific IL-10 during TI in a murine model of allergic airway inflammation. While TI was effective in IL-10 competent mice, neutralizing IL-10 prior to tolerogenic treatment completely abrogated the beneficial effects. Cellular sources of IL-10 during TI were identified by using transcriptional reporter mice as T cells, B cells, and to a lesser extent DCs. Interestingly, TI was still effective in mice with T cell, B cell, B and T cell, or DC-specific IL-10 deficiency. In contrast, TI was not possible inmice lacking IL-10 in all hematopoetic cells, while it was effective in bone marrow (BM) chimera that lacked IL-10 only in nonhematopoetic cells. Taken together, allergen-specific tolerance depends on IL-10 from hematopoetic sources. The beneficial effects of allergen-specific immunotherapy cannot solely be attributed to IL-10 from T cells, B cells, or even DCs, suggesting a high degree of cellular redundancy in IL-10-mediated tolerance.

Harvard Citation style: Kunz, S., Dolch, A., Surianarayanan, S., Dorn, B., Bewersdorff, M., Alessandrini, F., et al. (2016) T cell derived IL-10 is dispensable for tolerance induction in a murine model of allergic airway inflammation, European Journal of Immunology, 46(8), pp. 2018-2027. https://doi.org/10.1002/eji.201646319

APA Citation style: Kunz, S., Dolch, A., Surianarayanan, S., Dorn, B., Bewersdorff, M., Alessandrini, F., Behrendt, R., Karp, C., Muller, W., Martin, S., Roers, A., & Jakob, T. (2016). T cell derived IL-10 is dispensable for tolerance induction in a murine model of allergic airway inflammation. European Journal of Immunology. 46(8), 2018-2027. https://doi.org/10.1002/eji.201646319