Journal article

Publication year: 2016

Pages: 841-851

Journal: Biomarkers in Medicine

Volume number: 10

Issue number: 8

ISSN: 1752-0363

eISSN: 1752-0371

DOI Link: https://doi.org/10.2217/bmm-2016-0098

Publisher: Taylor and Francis

Abstract: 
Aim: This multicenter study investigated the effect of renal denervation therapy (RDN) on the heart failure related biomarkers NT-proBNP, ST-2, galectin-3 and hs-TnI. Patients & methods: We included 157 patients with resistant hypertension undergoing RDN. Blood sampling was performed before and 6 months after RDN. Results: Six months after RDN systolic blood pressure (BP) was reduced by 24 mmHg. Biomarker concentrations were not changed after RDN, except a small increase of hs-TnI by 0.3 pg/ml. In individuals with high baseline BP, we observed a BP reduction of 45 mmHg and a decrease of hs-TnI concentrations by 1.2 pg/ml. Conclusion: In this multicenter analysis RDN did significantly reduce systolic BP. However, NT-proBNP, ST-2, galectin-3 and hs-TnI did not correspond to BP reduction 6 months after RDN.

Harvard Citation style: Neumann, J., Ewen, S., Mortensen, K., Nef, H., Zeller, T., Ojeda, F., et al. (2016) Effects of renal denervation on heart failure biomarkers and blood pressure in patients with resistant hypertension, Biomarkers in Medicine, 10(8), pp. 841-851. https://doi.org/10.2217/bmm-2016-0098

APA Citation style: Neumann, J., Ewen, S., Mortensen, K., Nef, H., Zeller, T., Ojeda, F., Sydow, K., Mahfoud, F., Boehm, M., Hamm, C., Doerr, O., & Blankenberg, S. (2016). Effects of renal denervation on heart failure biomarkers and blood pressure in patients with resistant hypertension. Biomarkers in Medicine. 10(8), 841-851. https://doi.org/10.2217/bmm-2016-0098