Journal article

Publication year: 2016

Pages: 542-553

Journal: Materials Science and Engineering: C

Volume number: 67

ISSN: 0928-4931

eISSN: 1873-0191

DOI Link: https://doi.org/10.1016/j.msec.2016.05.042

Publisher: Elsevier

Abstract: 
For a targeted release against bacteria-associated bone diseases (osteomyelitis) ceramic beads with a high drug loading capacity, loaded with vancomycin as model antibiotic, are synthesized as drug carrier and successfully incorporated in an open porous hydroxyapatite matrix scaffold via freeze gelation to prevent bead migration at the implantation site and to extend drug release. We demonstrate that the quantity of loaded drug by the hydroxyapatite and beta-tricalcium phosphate beads, produced by ionotropic gelation, as well as drug release can be tuned and controlled by the selected calcium phosphate powder, sintering temperature, and high initial vancomycin concentrations (100 mg/ml) used for loading. Bead pore volume up to 68 mm(3)/g, with sufficiently large open pores (pore size of up to 650 nm with open porosity of 72%) and high surface area (91 m(2)/g) account like-Wise for a maximum drug loading of 236 mg/g beads or 26 mg/sample. Multi-drug loading of the beads/matrix composite can further increase the maximum loadable amount of vancomycin to 37 mg/sample and prolong release and antibacterial activity on Bacillus subtilis up to 5 days. The results confirmed that our approach to incorporate ceramic beads as drug carrier for highly increased drug load in freeze-gelated matrix scaffolds is feasible and may lead to a sustained drug release and antibacterial activity. (C) 2016 Published by Elsevier B.V.

Harvard Citation style: Hess, U., Mikolajczyk, G., Treccani, L., Streckbein, P., Heiss, C., Odenbach, S., et al. (2016) Multi-loaded ceramic beads/matrix scaffolds obtained by combining ionotropic and freeze gelation for sustained and tuneable vancomycin release, Materials Science and Engineering: C, 67, pp. 542-553. https://doi.org/10.1016/j.msec.2016.05.042

APA Citation style: Hess, U., Mikolajczyk, G., Treccani, L., Streckbein, P., Heiss, C., Odenbach, S., & Rezwan, K. (2016). Multi-loaded ceramic beads/matrix scaffolds obtained by combining ionotropic and freeze gelation for sustained and tuneable vancomycin release. Materials Science and Engineering: C. 67, 542-553. https://doi.org/10.1016/j.msec.2016.05.042