Journalartikel
Autorenliste: Wolter, Aline; Nosbuesch, Sina; Kawecki, Andreea; Degenhardt, Jan; Enzensberger, Christian; Graupner, Oliver; Vorisek, Carina; Akintuerk, Hakan; Yerebakan, Can; Khalil, Markus; Schranz, Dietmar; Ritgen, Jochen; Stressig, Ruediger; Axt-Fliedner, Roland
Jahr der Veröffentlichung: 2016
Seiten: 545-554
Zeitschrift: Prenatal Diagnosis
Bandnummer: 36
Heftnummer: 6
ISSN: 0197-3851
eISSN: 1097-0223
DOI Link: https://doi.org/10.1002/pd.4821
Verlag: Wiley
ObjectiveFunctionally univentricular hearts (UVHs) represent cardiac anomalies in which either the pulmonary or systemic circulation cannot be supported independently. The purpose of our study was to determine perinatal outcomes after prenatal diagnosis of functionally UVH. MethodsWe retrospectively evaluated patients who presented between 2008 and June 2015 in our centre and in prenatal practice praenatal.de in Cologne. We included double inlet left ventricle (DILV), tricuspid valve atresia (TA), pulmonary valve atresia and intact ventricular septum (PA:IVS), unbalanced atrioventricular septal defect (AVSD), heterotaxy, hypoplastic left heart syndrome (HLHS) and hypoplastic left heart complex (HLHC). ResultsOf initially 155 patients, 128 were liveborn (82.6%). Ten neonates (7.8%) were lost to follow-up, in three (2.5%) neonates, parents decided for compassionate care. Overall survival after prenatal diagnosis of functionally UVH was 67.1%, and 90.4% on an intention-to-treat basis. Survival after surgery reached 93.7%. The majority of deaths occurred within the group of dominant RV (10/74, 13.5%). High risk HLHS with restrictive foramen ovale was associated with the lowest survival rate (13/17, 76.5%) with significant difference compared to survival rate in dominant LV (40/41, 97.6%, p<0.05). ConclusionThese results should be explained to parents to ensure informed decisions and counselling. (c) 2016 John Wiley & Sons, Ltd.
Abstract:
Zitierstile
Harvard-Zitierstil: Wolter, A., Nosbuesch, S., Kawecki, A., Degenhardt, J., Enzensberger, C., Graupner, O., et al. (2016) Prenatal diagnosis of functionally univentricular heart, associations and perinatal outcomes, Prenatal Diagnosis, 36(6), pp. 545-554. https://doi.org/10.1002/pd.4821
APA-Zitierstil: Wolter, A., Nosbuesch, S., Kawecki, A., Degenhardt, J., Enzensberger, C., Graupner, O., Vorisek, C., Akintuerk, H., Yerebakan, C., Khalil, M., Schranz, D., Ritgen, J., Stressig, R., & Axt-Fliedner, R. (2016). Prenatal diagnosis of functionally univentricular heart, associations and perinatal outcomes. Prenatal Diagnosis. 36(6), 545-554. https://doi.org/10.1002/pd.4821
Schlagwörter
HYPOPLASTIC LEFT-HEART; PALLIATION
