Journal article

Publication year: 2016

Journal: PLoS ONE

Volume number: 11

Issue number: 6

ISSN: 1932-6203

Open access status: Gold

DOI Link: https://doi.org/10.1371/journal.pone.0156929

Publisher: Public Library of Science

Abstract: 
In addition to their well-known antibacterial activity some antimicrobial peptides and proteins (AMPs) display also antiviral effects. A 27 aa peptide from the N-terminal part of human bactericidal/permeability-increasing protein (BPI) previously shown to harbour antibacterial activity inhibits the infectivity of multiple Influenza A virus strains (H1N1, H3N2 and H5N1) the causing agent of the Influenza pneumonia. In contrast, the homologous murine BPI-peptide did not show activity against Influenza A virus. In addition human BPI-peptide inhibits the activation of immune cells mediated by Influenza A virus. By changing the human BPI-peptide to the sequence of the mouse homologous peptide the antiviral activity was completely abolished. Furthermore, the human BPI-peptide also inhibited the pathogenicity of the Vesicular Stomatitis Virus but failed to interfere with HIV and measles virus. Electron microscopy indicate that the human BPI-peptide interferes with the virus envelope and at high concentrations was able to destroy the particles completely.

Harvard Citation style: Pinkenburg, O., Meyer, T., Bannert, N., Norley, S., Bolte, K., Czudai-Matwich, V., et al. (2016) The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus, PLoS ONE, 11(6), Article e0156929. https://doi.org/10.1371/journal.pone.0156929

APA Citation style: Pinkenburg, O., Meyer, T., Bannert, N., Norley, S., Bolte, K., Czudai-Matwich, V., Herold, S., Gessner, A., & Schnare, M. (2016). The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus. PLoS ONE. 11(6), Article e0156929. https://doi.org/10.1371/journal.pone.0156929