Journal article
Authors list: Garn, Holger; Bahn, Sabine; Baune, Bernhard T.; Binder, Elisabeth B.; Bisgaard, Hans; Chatila, Talal A.; Chavakis, Triantafyllos; Culmsee, Carsten; Dannlowski, Udo; Gay, Steffen; Gern, James; Haahtela, Tari; Kircher, Tilo; Mueller-Ladner, Ulf; Neurath, Markus F.; Preissner, Klaus T.; Reinhardt, Christoph; Rook, Graham; Russell, Shannon; Schmeck, Bernd; Stappenbeck, Thaddeus; Steinhoff, Ulrich; van Os, Jim; Weiss, Scott; Zemlin, Michael; Renz, Harald
Publication year: 2016
Pages: 47-56
Journal: Journal of Allergy and Clinical Immunology
Volume number: 138
Issue number: 1
ISSN: 0091-6749
eISSN: 1097-6825
Open access status: Green
DOI Link: https://doi.org/10.1016/j.jaci.2016.02.046
Publisher: Elsevier
Abstract:
Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Rontgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.
Citation Styles
Harvard Citation style: Garn, H., Bahn, S., Baune, B., Binder, E., Bisgaard, H., Chatila, T., et al. (2016) Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation, Journal of Allergy and Clinical Immunology, 138(1), pp. 47-56. https://doi.org/10.1016/j.jaci.2016.02.046
APA Citation style: Garn, H., Bahn, S., Baune, B., Binder, E., Bisgaard, H., Chatila, T., Chavakis, T., Culmsee, C., Dannlowski, U., Gay, S., Gern, J., Haahtela, T., Kircher, T., Mueller-Ladner, U., Neurath, M., Preissner, K., Reinhardt, C., Rook, G., Russell, S., ...Renz, H. (2016). Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. Journal of Allergy and Clinical Immunology. 138(1), 47-56. https://doi.org/10.1016/j.jaci.2016.02.046
Keywords
allergic disease; ANTIBIOTIC USE; EARLY-LIFE; EXTRACELLULAR RNA; gut microbiota; immune dysregulation; INTESTINAL MICROBIOTA; RHEUMATOID-ARTHRITIS; SCHIZOPHRENIA-PATIENTS
