Journal article

Publication year: 2016

Pages: 733-745

Journal: Histology and Histopathology

Volume number: 31

Issue number: 7

ISSN: 0213-3911

eISSN: 1699-5848

DOI Link: https://doi.org/10.14670/HH-11-746

Publisher: Universidad de Murcia

Abstract: 
The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellular matrix proteins, proteases and protease/inhibitor complexes and growth factors. Interactions with other membrane receptors and intracellular adaptors/scaffolding proteins allow LRP1 to modulate cell migration, survival, proliferation and (trans) differentiation. Because LRP1 displays a wide-range of interactions and activities, its expression and function is temporally and spatially tightly controlled. It is not, therefore, surprising that deregulation of LRP1 production and/or activity is observed in several diseases. In this review, we will systematically examine the evidence for the role of LRP1 in human pathologies placing special emphasis on LRP1-mediated pathogenesis of the lung.

Harvard Citation style: Wujak, L., Markart, P. and Wygrecka, M. (2016) The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases, Histology and Histopathology, 31(7), pp. 733-745. https://doi.org/10.14670/HH-11-746

APA Citation style: Wujak, L., Markart, P., & Wygrecka, M. (2016). The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases. Histology and Histopathology. 31(7), 733-745. https://doi.org/10.14670/HH-11-746