Journal article

Publication year: 2016

Pages: 1298-1303

Journal: Catheterization & Cardiovascular Interventions

Volume number: 87

Issue number: 7

ISSN: 1522-1946

eISSN: 1522-726X

DOI Link: https://doi.org/10.1002/ccd.26355

Publisher: Wiley

Abstract: 
Previous studies of renal sympathetic denervation (RSD) excluded patients with impaired renal function to avoid potential RSD-related renal damage. Measurement of the highly sensitive biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) has shown that RSD does not aggravate renal damage during the early post-procedural period. The aim of the present study was to examine the effect of RSD on blood pressure (BP) reduction and renal function after a long-term follow-up. A total of 62 consecutive patients undergoing RSD were included in this study. Serum NGAL and KIM-1 were collected prior to RSD and at 24 hr, 48 hr, and 3 months after RSD. BP measurements, antihypertensive medication use, and safety events were followed over a three-year period. Follow-up data were available over 36.9[+/- 3.4] months in 47 of 62 (75.8%) of the initially included patients. At this time point a significant systolic BP reduction of 23 mm Hg (P > 0.001) was documented, and there were no significant changes in serum creatinine (P=0.14), blood urea nitrogen (P=0.33), or estimated glomerular filtration rate (eGFR) (P=0.2) values. There were also no significant changes documented in patients with impaired renal function (eGFR < 45 mL/min) during the early post-procedural period or the long-term follow-up (P=0.34). The results of the present study show a sustained effect of RSD on BP reduction after a three-year follow-up, and there was no evidence of renal failure. These results provide verification of the long-term safety and effectiveness of RSD, even in patients with impaired renal function. (C) 2015 Wiley Periodicals, Inc.

Harvard Citation style: Doerr, O., Liebetrau, C., Moellmann, H., Gaede, L., Troidl, C., Wiebe, J., et al. (2016) Long-Term Verification of Functional and Structural Renal Damage After Renal Sympathetic Denervation, Catheterization & Cardiovascular Interventions, 87(7), pp. 1298-1303. https://doi.org/10.1002/ccd.26355

APA Citation style: Doerr, O., Liebetrau, C., Moellmann, H., Gaede, L., Troidl, C., Wiebe, J., Renker, M., Bauer, T., Hamm, C., & Nef, H. (2016). Long-Term Verification of Functional and Structural Renal Damage After Renal Sympathetic Denervation. Catheterization & Cardiovascular Interventions. 87(7), 1298-1303. https://doi.org/10.1002/ccd.26355