Journal article
Authors list: Doerr, Oliver; Liebetrau, Christoph; Moellmann, Helge; Gaede, Luise; Troidl, Christian; Lankes, Simone; Guckel, Denise; Boeder, Niklas; Voss, Sandra; Bauer, Timm; Hamm, Christian; Nef, Holger
Publication year: 2016
Pages: 497-502
Journal: The journal of clinical hypertension
Volume number: 18
Issue number: 6
ISSN: 1524-6175
eISSN: 1751-7176
Open access status: Green
DOI Link: https://doi.org/10.1111/jch.12797
Publisher: Wiley
Abstract:
A total of 90 consecutive patients undergoing renal sympathetic denervation (RSD) were included in this study. A significant reduction in office systolic blood pressure (SBP) of 21.1 mm Hg (P<.001) was documented 6 months after RSD. At this time point, circulating concentrations of microRNA (miR)-133a were significantly increased (sevenfold; P<.001) compared with baseline values. Correlation analysis showed a significant relationship between baseline SBP values and SBP reduction (P<.001) as well as between miR-133a baseline levels and the increase in miR-133a expression (P<.001) after the 6-month follow-up. The effect of RSD on miR-133a expression was significantly greater in patients at high risk for hypertensive heart disease. In addition to the effective blood pressure reduction in response to RSD, this study demonstrates an effect of RSD on miR reflecting cardiovascular reverse remodeling processes. Thus, these results provide information on a beneficial effect of RSD on cardiac recovery in patients at high risk for hypertensive heart disease.
Citation Styles
Harvard Citation style: Doerr, O., Liebetrau, C., Moellmann, H., Gaede, L., Troidl, C., Lankes, S., et al. (2016) Effect of Renal Sympathetic Denervation on Specific MicroRNAs as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease, The journal of clinical hypertension, 18(6), pp. 497-502. https://doi.org/10.1111/jch.12797
APA Citation style: Doerr, O., Liebetrau, C., Moellmann, H., Gaede, L., Troidl, C., Lankes, S., Guckel, D., Boeder, N., Voss, S., Bauer, T., Hamm, C., & Nef, H. (2016). Effect of Renal Sympathetic Denervation on Specific MicroRNAs as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease. The journal of clinical hypertension. 18(6), 497-502. https://doi.org/10.1111/jch.12797
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