Journal article
Authors list: Matricardi, P. M.; Kleine-Tebbe, J.; Hoffmann, H. J.; Valenta, R.; Hilger, C.; Hofmaier, S.; Aalberse, R. C.; Agache, I.; Asero, R.; Ballmer-Weber, B.; Barber, D.; Beyer, K.; Biedermann, T.; Bilo, M. B.; Blank, S.; Bohle, B.; Bosshard, P. P.; Breiteneder, H.; Brough, H. A.; Caraballo, L.; Caubet, J. C.; Crameri, R.; Davies, J. M.; Douladiris, N.; Ebisawa, M.; EIgenmann, P. A.; Fernandez-Rivas, M.; Ferreira, F.; Gadermaier, G.; Glatz, M.; Hamilton, R. G.; Hawranek, T.; Hellings, P.; Hoffmann-Sommergruber, K.; Jakob, T.; Jappe, U.; Jutel, M.; Kamath, S. D.; Knol, E. F.; Korosec, P.; Kuehn, A.; Lack, G.; Lopata, A. L.; Makela, M.; Morisset, M.; Niederberger, V.; Nowak-Wezgrzyn, A. H.; Papadopoulos, N. G.; Pastorello, E. A.; Pauli, G.; Platts-Mills, T.; Posa, D.; Poulsen, L. K.; Raulf, M.; Sastre, J.; Scala, E.; Schmid, J. M.; Schmid-Grendelmeier, P.; van Hage, M.; van Ree, R.; Vieths, S.; Weber, R.; Wickman, M.; Muraro, A.; Ollert, M.
Publication year: 2016
Pages: 1-250
Journal: Pediatric Allergy and Immunology
Volume number: 27
ISSN: 0905-6157
eISSN: 1399-3038
DOI Link: https://doi.org/10.1111/pai.12563
Publisher: Wiley
Abstract:
The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from primary sensitization. Part B discusses clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, molds, mites, animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food allergy, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.
Citation Styles
Harvard Citation style: Matricardi, P., Kleine-Tebbe, J., Hoffmann, H., Valenta, R., Hilger, C., Hofmaier, S., et al. (2016) EAACI Molecular Allergology User's Guide, Pediatric Allergy and Immunology, 27, pp. 1-250. https://doi.org/10.1111/pai.12563
APA Citation style: Matricardi, P., Kleine-Tebbe, J., Hoffmann, H., Valenta, R., Hilger, C., Hofmaier, S., Aalberse, R., Agache, I., Asero, R., Ballmer-Weber, B., Barber, D., Beyer, K., Biedermann, T., Bilo, M., Blank, S., Bohle, B., Bosshard, P., Breiteneder, H., Brough, H., ...Ollert, M. (2016). EAACI Molecular Allergology User's Guide. Pediatric Allergy and Immunology. 27, 1-250. https://doi.org/10.1111/pai.12563
Keywords
ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; allergy diagnosis; anaphylaxis; ARA H 2; Atopic dermatitis; BET V 1; BIRCH POLLEN ALLERGEN; COMPONENT-RESOLVED DIAGNOSIS; COWS MILK ALLERGY; CROSS-REACTIVE ALLERGEN; diagnostic algorithms; GUIDELINES; HOUSE-DUST MITE; IGE; IgE cross-reactivity; LIPID-TRANSFER PROTEIN; lipocalins; molecular allergology; NATURAL-RUBBER LATEX; non-specific lipid transfer proteins; panallergens; parvalbumins; pathogenesis-related protein family 10; polcalcins; Precision medicine; profilins; serum albumins; tropomyosins
