Journalartikel
Autorenliste: Mueller, F. H. H.; Farahati, J.; Mueller, A. G.; Gillman, E.; Hentschel, M.
Jahr der Veröffentlichung: 2016
Seiten: 15-20
Zeitschrift: Nuclear Medicine
Bandnummer: 55
Heftnummer: 1
ISSN: 0029-5566
DOI Link: https://doi.org/10.3413/Nukmed-0753-15-07
Verlag: Schattauer
Abstract:
Aim: To evaluate the diagnostic value (sensitivity, specificity) of positron emission mammography (PEM) in a single site non-interventional study using the maximum PEM uptake value (PUVmax). Patients, methods: In a singlesite, non-interventional study, 108 patients (107 women, 1 man) with a total of 151 suspected lesions were scanned with a PEM Flex Solo II (Naviscan) at 90 min p.i. with 3.5 MBq F-18-FDG per kg of body weight. In this ROI(region of interest)-based analysis, maximum PEM uptake value (PUV) was determined in lesions, tumours (PUVmax(tumour)), benign lesions (PUVmax(normal) (breast)) and also in healthy tissues on the contralateral side (PUVMax(contralateral) (breast)). These values were compared and contrasted. In addition, the ratios of PUVmax(tumour)/PUVmax(contralateral) (breast) and PUVmax(normal) (breast)/PUVMax(contralateral) (breast) were compared. The image data were interpreted independently by two experienced nuclear medicine physicians and compared with histology in cases of suspected carcinoma. Results: Based on a criteria of PUV>1.9, 31 out of 151 lesions in the patient cohort were found to be malignant (21%). A mean PUVmaxtumour of 3.78 +/- 2.47 was identified in malignant tumours, while a mean PUVmaxnormal breast of 1.17 +/- 0.37 was reported in the glandular tissue of the healthy breast, with the difference being statistically significant (p < 0.001). Similarly, the mean ratio between tumour and healthy glandular tissue in breast cancer patients (3.15 +/- 1.58) was found to be significantly higher than the ratio for benign lesions (1.17 0.41, p < 0.001). Conclusion: PEM is capable of differentiating breast tumours from benign lesions with 100% sensitivity along with a high specificity of 96%, when a threshold of PUVmax >1.9 is applied.
Zitierstile
Harvard-Zitierstil: Mueller, F., Farahati, J., Mueller, A., Gillman, E. and Hentschel, M. (2016) Positron emission mammography in the diagnosis of breast cancer Is maximum PEM uptake value a valuable threshold for malignant breast cancer detection?, Nuclear Medicine, 55(1), pp. 15-20. https://doi.org/10.3413/Nukmed-0753-15-07
APA-Zitierstil: Mueller, F., Farahati, J., Mueller, A., Gillman, E., & Hentschel, M. (2016). Positron emission mammography in the diagnosis of breast cancer Is maximum PEM uptake value a valuable threshold for malignant breast cancer detection?. Nuclear Medicine. 55(1), 15-20. https://doi.org/10.3413/Nukmed-0753-15-07
Schlagwörter
benign tumours; FDG; malign tumours; Positron emission tomography; TOMOGRAPHY
