Prediction of Locally Advanced Urothelial Carcinoma of the Bladder Using Clinical Parameters before Radical Cystectomy - A Prospective Multicenter Study - Forschungsportal der Justus-Liebig-Universität Gießen:

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Prediction of Locally Advanced Urothelial Carcinoma of the Bladder Using Clinical Parameters before Radical Cystectomy - A Prospective Multicenter Study

Autorenliste: Martini, Thomas; Aziz, Atiqullah; Roghmann, Florian; Rink, Michael; Chun, Felix K.; Fisch, Margit; Trojan, Lutz; Hakenberg, Oliver W.; Zastrow, Stefan; Wirth, Manfred P.; Moersdorf, Johannes; Brookman-May, Sabine; Stief, Christian G.; Haferkamp, Axel; Wagenlehner, Florian; Hohenfellner, Markus; Herrmann, Edwin; Lusuardi, Lukas; Grimm, Marc -Oliver; Mueller, Stephan C.; Roigas, Jan; Bastian, Patrick J.; Gierth, Michael; Burger, Maximilian; Pychar, Armin; Seitz, Christian; May, Matthias; Bolenz, Christian

Jahr der Veröffentlichung: 2016

Seiten: 57-64

Zeitschrift: Urologia Internationalis

Bandnummer: 96

Heftnummer: 1

ISSN: 0042-1138

eISSN: 1423-0399

Open Access Status: Green

DOI Link: https://doi.org/10.1159/000433606

Verlag: Karger Publishers

Abstract:
Introduction: We aimed at developing and validating a pre-cystectomy nomogram for the prediction of locally advanced urothelial carcinoma of the bladder (UCB) using clinicopathological parameters. Materials and Methods: Multicenter data from 337 patients who underwent radical cystectomy (RC) for UCB were prospectively collected and eligible for final analysis. Univariate and multivariate logistic regression models were applied to identify significant predictors of locally advanced tumor stage (pT3/4 and/or pN+) at RC. Internal validation was performed by bootstrapping. The decision curve analysis (DCA) was done to evaluate the clinical value. Results: The distribution of tumor stages pT3/4, pN+ and pT3/4 and/or pN+ at RC was 44.2, 27.6 and 50.4%, respectively. Age (odds ratio (OR) 0.980; p < 0.001), advanced clinical tumor stage (cT3 vs. cTa, cTis, cT1; OR 3.367; p < 0.001), presence of hydronephrosis (OR 1.844; p = 0.043) and advanced tumor stage T3 and/or N+ at CT imaging (OR 4.378; p < 0.001) were independent predictors for pT3/4 and/or pN+ tumor stage. The predictive accuracy of our nomogram for pT3/4 and/or pN+ at RC was 77.5%. DCA for predicting pT3/4 and/or pN+ at RC showed a clinical net benefit across all probability thresholds. Conclusion: We developed a nomogram for the prediction of locally advanced tumor stage pT3/4 and/or pN+ before RC using established clinicopathological parameters. (C) 2015 S. Karger AG, Basel

Zitierstile

Harvard-Zitierstil: Martini, T., Aziz, A., Roghmann, F., Rink, M., Chun, F., Fisch, M., et al. (2016) Prediction of Locally Advanced Urothelial Carcinoma of the Bladder Using Clinical Parameters before Radical Cystectomy - A Prospective Multicenter Study, Urologia Internationalis, 96(1), pp. 57-64. https://doi.org/10.1159/000433606

APA-Zitierstil: Martini, T., Aziz, A., Roghmann, F., Rink, M., Chun, F., Fisch, M., Trojan, L., Hakenberg, O., Zastrow, S., Wirth, M., Moersdorf, J., Brookman-May, S., Stief, C., Haferkamp, A., Wagenlehner, F., Hohenfellner, M., Herrmann, E., Lusuardi, L., Grimm, M., ...Bolenz, C. (2016). Prediction of Locally Advanced Urothelial Carcinoma of the Bladder Using Clinical Parameters before Radical Cystectomy - A Prospective Multicenter Study. Urologia Internationalis. 96(1), 57-64. https://doi.org/10.1159/000433606

Zitierstile

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