Journal article

Publication year: 2016

Pages: 128-137

Journal: Journal of Vascular Research

Volume number: 53

Issue number: 3-4

ISSN: 1018-1172

eISSN: 1423-0135

DOI Link: https://doi.org/10.1159/000449386

Publisher: Karger Publishers

Abstract: 
Background: Patients with acute ischemic strokes frequently take an acetylsalicylic acid (ASA) premedication. We determined the impact of ASA on different thrombolysis strategies in vitro. Methods: For two clot types made from plate-let- rich plasma (one with and one without ASA) lysis rates were measured by weight loss after 1 h for five different groups: in control group A clots were solely placed in plasma; in groups B and C clots were treated with rt-PA (60 kU/ml), and in groups D and E clots were treated with desmoteplase (DSPA; 2 mu g/ml). Ultrasound (2 MHz, 0.179 W/cm(2)) was included in groups C and E. The fibrin mesh structures of the clots were investigated by electron microscopy. Results: For both clot types lysis rates increased significantly for all treatment strategies compared to their control group (each p < 0.001). The addition of ASA significantly increased the lysis rate in all 5 groups (each p < 0.001) and led to a ceiling effect concerning the treatment. A semiquantitative analysis of transmission electron micrographs revealed a decreased fibrin density for clots with ASA. For both clot types DSPA and ultrasound led to a significant dissolution of the fibrin mesh (both p = 0.029). Conclusions: In vitro ASA pretreatment leads to significantly increased lysis rates due to a weaker fibrin mesh in platelet-rich plasma clots. (C) 2016 S. Karger AG, Basel

Harvard Citation style: Roessler, F., Schumacher, S., Sprenger, A., Gaertner, U., Al-Khaled, M. and Eggers, J. (2016) Clot Formation in the Presence of Acetylsalicylic Acid Leads to Increased Lysis Rates Regardless of the Chosen Thrombolysis Strategy, Journal of Vascular Research, 53(3-4), pp. 128-137. https://doi.org/10.1159/000449386

APA Citation style: Roessler, F., Schumacher, S., Sprenger, A., Gaertner, U., Al-Khaled, M., & Eggers, J. (2016). Clot Formation in the Presence of Acetylsalicylic Acid Leads to Increased Lysis Rates Regardless of the Chosen Thrombolysis Strategy. Journal of Vascular Research. 53(3-4), 128-137. https://doi.org/10.1159/000449386