Journalartikel
Autorenliste: Guenther, Anke L. B.; Schulze, Matthias B.; Kroke, Anja; Diethelm, Katharina; Joslowski, Gesa; Krupp, Danika; Wudy, Stefan; Buyken, Anette E.
Jahr der Veröffentlichung: 2015
Seiten: 877-892
Zeitschrift: Nutrition and Cancer
Bandnummer: 67
Heftnummer: 6
ISSN: 0163-5581
eISSN: 1532-7914
DOI Link: https://doi.org/10.1080/01635581.2015.1056313
Verlag: Taylor and Francis Group
Abstract:
Early life, adiposity rebound, and puberty represent critical growth periods when food choices could have long-term relevance for cancer risk. We aimed to relate dietary patterns during these periods to the growth hormone-insulin-like-growth-factor (GH-IGF) axis, insulin resistance, and body fatness in adulthood. Data from the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) Study participants with outcome data at 18-37years, and 2 dietary records during early life (1-2yr; n = 128), adiposity rebound (4-6years, n = 179), or puberty (girls 9-14, boys 10-15yr; n = 213) were used. Dietary patterns at these ages were derived by 1) reduced rank regression (RRR) to explain variation in adult IGF-I, IGF-binding protein-3 (IGFBP-3), homoeostasis model assessment for insulin resistance (HOMA-IR) and fat-mass index; 2) principal component analysis (PCA). Regarding RRR, the patterns cake/canned fruit/cheese & eggs (early life), sweets & dairy (adiposity rebound) and high-fat foods (pubertal boys) were independently associated with higher adult HOMA-IR. Furthermore, the patterns favorable carbohydrate sources (early life), snack & convenience foods (adiposity rebound), and traditional & convenience carbohydrates (pubertal boys) were related to adult IGFBP-3 (P trend < 0.01). PCA identified healthy patterns for all periods, but none was associated with the outcomes (P trend > 0.1). In conclusion, dietary patterns during sensitive growth periods may be of long-term relevance for adult insulin resistance and IGFBP-3.
Zitierstile
Harvard-Zitierstil: Guenther, A., Schulze, M., Kroke, A., Diethelm, K., Joslowski, G., Krupp, D., et al. (2015) Early Diet and Later Cancer Risk: Prospective Associations of Dietary Patterns During Critical Periods of Childhood with the GH-IGF Axis, Insulin Resistance and Body Fatness in Younger Adulthood, Nutrition and Cancer, 67(6), pp. 877-892. https://doi.org/10.1080/01635581.2015.1056313
APA-Zitierstil: Guenther, A., Schulze, M., Kroke, A., Diethelm, K., Joslowski, G., Krupp, D., Wudy, S., & Buyken, A. (2015). Early Diet and Later Cancer Risk: Prospective Associations of Dietary Patterns During Critical Periods of Childhood with the GH-IGF Axis, Insulin Resistance and Body Fatness in Younger Adulthood. Nutrition and Cancer. 67(6), 877-892. https://doi.org/10.1080/01635581.2015.1056313
Schlagwörter
BINDING PROTEIN-3; EARLY-LIFE; FACTOR-I; GLYCEMIC LOAD; GROWTH-FACTOR (IGF)-I
