Journal article

Publication year: 2015

Pages: 310-316

Journal: Journal of Cystic Fibrosis

Volume number: 14

Issue number: 3

ISSN: 1569-1993

eISSN: 1873-5010

Open access status: Bronze

DOI Link: https://doi.org/10.1016/j.jcf.2014.09.006

Publisher: Elsevier

Abstract: 

Background: The current practice of averaging the nasal potential difference (NPD) results of right and left nostril measurements reduce inter-individual variability but may underestimate individual CFTR function.

Methods: Best NPD response to Cl--free and isdproterenol perfusion (=largest Delta PD0Cl/Iso) from the right and left nostril was compared to the average result in 13 cystic fibrosis (CF), 78 query-CF patients and 22 healthy controls from 2 cohorts.

Results: Despite moderate to good correlation (p < 0.001) between right and left measured Delta PD0Cl/Iso, we observed large differences in some individuals. A comparison of average versus best Delta PD0Cl/Iso showed only moderate agreement (Giessen kappa = 0.538; Toronto kappa = 0.607). Averaging Delta PD0Cl/Iso showed a lower composite chloride response compared to best Delta PD0Cl/Iso and altered diagnostic NPD interpretation in 30 of 113 (27%) subjects.

Conclusions: The current practice of averaging the NPD results of right and left nostril measurements leads to an underestimation of the individual CFTR function and should be reconsidered. (C) 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Harvard Citation style: Keenan, K., Avolio, J., Rueckes-Nilges, C., Tullis, E., Gonska, T. and Naehrlich, L. (2015) Nasal potential difference: Best or average result for CFTR function as diagnostic criteria for cystic fibrosis?, Journal of Cystic Fibrosis, 14(3), pp. 310-316. https://doi.org/10.1016/j.jcf.2014.09.006

APA Citation style: Keenan, K., Avolio, J., Rueckes-Nilges, C., Tullis, E., Gonska, T., & Naehrlich, L. (2015). Nasal potential difference: Best or average result for CFTR function as diagnostic criteria for cystic fibrosis?. Journal of Cystic Fibrosis. 14(3), 310-316. https://doi.org/10.1016/j.jcf.2014.09.006