Journalartikel

Jahr der Veröffentlichung: 2015

Seiten: 767-775

Zeitschrift: Diabetes Care

Bandnummer: 38

Heftnummer: 5

ISSN: 0149-5992

eISSN: 1935-5548

DOI Link: https://doi.org/10.2337/dc14-1599

Verlag: American Diabetes Association

Abstract: 
OBJECTIVEThis study compared the long-term efficacy of a diabetes-specific cognitive behavioral group therapy (CBT) with sertraline in patients with diabetes and depression who initially responded to short-term depression treatment.RESEARCH DESIGN AND METHODSA randomized controlled single-blind trial was conducted in 70 secondary care centers across Germany comparing 12 weeks of CBT with sertraline in 251 patients with type 1 or 2 diabetes (mean HbA(1c) 9.3%, 78 mmol/mol) and major depression (Structured Clinical Interview for DSM-IV [SCID]). After 12 weeks, treatment responders (50% reduction Hamilton Depression Rating Scale [HAMD-17]) were included in the 1-year study phase where CBT patients were encouraged to use bibliotherapy and sertraline patients received continuous treatment. We analyzed differences for HbA(1c) (primary outcome) and reduction (HAMD-17) or remission (SCID) of depression from baseline to the 1-year follow-up using ANCOVA or logistic regression analysis.RESULTSAfter 12 weeks, 45.8% of patients responded to antidepressant treatment and were included in the 1-year study phase. Adjusted HbA(1c) mean score changes from baseline to the end of the long-term phase (-0.27, 95% CI -0.62 to 0.08) revealed no significant difference between interventions. Depression improved in both groups, with a significant advantage for sertraline (HAMD-17 change: -2.59, 95% CI 1.15-4.04, P < 0.05).CONCLUSIONSDepression improved under CBT and sertraline in patients with diabetes and depression, with a significant advantage for sertraline, but glycemic control remained unchanged. CBT and sertraline as single treatment are insufficient to treat secondary care diabetes patients with depression and poor glycemic control.

Harvard-Zitierstil: Petrak, F., Herpertz, S., Albus, C., Hermanns, N., Hiemke, C., Hiller, W., et al. (2015) Cognitive Behavioral Therapy Versus Sertraline in Patients With Depression and Poorly Controlled Diabetes: The Diabetes and Depression (DAD) Study A Randomized Controlled Multicenter Trial, Diabetes Care, 38(5), pp. 767-775. https://doi.org/10.2337/dc14-1599

APA-Zitierstil: Petrak, F., Herpertz, S., Albus, C., Hermanns, N., Hiemke, C., Hiller, W., Kronfeld, K., Kruse, J., Kulzer, B., Ruckes, C., Zahn, D., & Mueller, M. (2015). Cognitive Behavioral Therapy Versus Sertraline in Patients With Depression and Poorly Controlled Diabetes: The Diabetes and Depression (DAD) Study A Randomized Controlled Multicenter Trial. Diabetes Care. 38(5), 767-775. https://doi.org/10.2337/dc14-1599