Journal article

Publication year: 2015

Pages: 452-463

Journal: Thrombosis and Haemostasis

Volume number: 113

Issue number: 3

ISSN: 0340-6245

eISSN: 2567-689X

DOI Link: https://doi.org/10.1160/TH14-06-0497

Publisher: Thieme Publishing

Abstract: 
It is well established that the heart is strongly dependent on fatty acid metabolism. In cardiomyocytes there are two distinct sites for the beta-oxidisation of fatty acids: the mitochondrion and the peroxisome. Although the metabolism of these two organelles is believed to be tightly coupled, the nature of this relationship has not been fully investigated. Recent research has established the significant contribution of mitochondrial function to cardiac ATP production under normal and pathological conditions. In contrast, limited information is available on peroxisomal function in the heart. This is despite these organelles harbouring metabolic pathways that are potentially cardio-protective, and findings that patients with peroxisomal diseases, such as adult Refsum's disease, can develop heart failure. In this article, we provide a comprehensive overview on the current knowledge of peroxisomes and the regulation of lipid metabolism by PPARs in cardiomyocytes. We also present new experimental evidence on the differential expression of peroxisome-related genes in the heart chambers and demonstrate that even a mild peroxisomal biogenesis defect (Pex11 alpha(-/-)) can induce profound alterations in the cardiomyocyte's peroxisomal compartment and related gene expression, including the concomitant deregulation of specific PPARs. The possible impact of peroxisomal dysfunction in the heart is discussed and a model for the 1 modulation of myocardial metabolism via a peroxisome/PPAR-loop is proposed.

Harvard Citation style: Colasante, C., Chen, J., Ahlemeyer, B. and Baumgart-Vogt, E. (2015) Peroxisomes in cardiomyocytes and the peroxisome/peroxisome proliferator-activated receptor-loop, Thrombosis and Haemostasis, 113(3), pp. 452-463. https://doi.org/10.1160/TH14-06-0497

APA Citation style: Colasante, C., Chen, J., Ahlemeyer, B., & Baumgart-Vogt, E. (2015). Peroxisomes in cardiomyocytes and the peroxisome/peroxisome proliferator-activated receptor-loop. Thrombosis and Haemostasis. 113(3), 452-463. https://doi.org/10.1160/TH14-06-0497