Journalartikel

Hepatitis B virus large surface protein: function and fame


AutorenlisteChurin, Yuri; Roderfeld, Martin; Roeb, Elke

Jahr der Veröffentlichung2015

Seiten1-10

ZeitschriftHepatobiliary Surgery and Nutrition

Bandnummer4

Heftnummer1

ISSN2304-3881

eISSN2304-389X

DOI Linkhttps://doi.org/10.3978/j.issn.2304-3881.2014.12.08

VerlagAME Publishing


Abstract
Chronic infection with hepatitis B virus (HBV) is the leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. HBV life cycle begins with viral attachment to hepatocytes, mediated by the large HBV surface protein (LHBs). Identification of the sodium-taurocholate cotransporting polypeptide (NTCP) as a HBV receptor has revealed a suitable target for viral entry inhibition. Analysis of serum hepatitis B surface antigen (HBsAg) level is a non-invasive diagnostic parameter that improves HBV treatment opportunities. Furthermore, HBsAg plays an important role in manipulation of host immune response by HBV. However, observations in patients with chronic hepatitis B under conditions of immune suppression and in transgenic mouse models of HBV infection suggest, that in absence of adaptive immune responses cellular mechanisms induced by HBV may also lead to the development of liver diseases. Thus, the multifaceted pathological aspects of HBsAg predetermine the design of new therapeutical options modulating associated biological implications.



Zitierstile

Harvard-ZitierstilChurin, Y., Roderfeld, M. and Roeb, E. (2015) Hepatitis B virus large surface protein: function and fame, Hepatobiliary surgery and nutrition, 4(1), pp. 1-10. https://doi.org/10.3978/j.issn.2304-3881.2014.12.08

APA-ZitierstilChurin, Y., Roderfeld, M., & Roeb, E. (2015). Hepatitis B virus large surface protein: function and fame. Hepatobiliary surgery and nutrition. 4(1), 1-10. https://doi.org/10.3978/j.issn.2304-3881.2014.12.08



Schlagwörter


CHRONIC HBV INFECTIONendoplasmic reticulum stress (ER stress)FIBROSING CHOLESTATIC HEPATITIShepatitis B virus (HBV)HEPATOCELLULAR-CARCINOMAhepatocellular carcinoma (HCC)LARGE ENVELOPE POLYPEPTIDENATURAL-HISTORYsodium taurocholate cotransporting polypeptideTRANSGENIC MICE


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