Journal article

Publication year: 2014

Journal: Frontiers in Cellular and Infection Microbiology

Volume number: 4

ISSN: 2235-2988

Open access status: Gold

DOI Link: https://doi.org/10.3389/fcimb.2014.00135

Publisher: Frontiers Media

Abstract: 
Listeria monocytogenes is a Gram-positive human-pathogen bacterium that served as an experimental model for investigating fundamental processes of adaptive immunity and virulence. Recent novel technologies allowed the identification of several hundred non-coding RNAs (ncRNAs) in the Listeria genome and provided insight into an unexpected complex transcriptional machinery. In this review, we discuss ncRNAs that are encoded on the opposite strand of the target gene and are therefore termed antisense RNAs (asRNAs). We highlight mechanistic and functional concepts of asRNAs in L. monocytogenes and put these in context of asRNAs in other bacteria. Understanding asRNAs will further broaden our knowledge of RNA-mediated gene regulation and may provide targets for diagnostic and antimicrobial development.

Harvard Citation style: Schultze, T., Izar, B., Qing, X., Mannala, G. and Hain, T. (2014) Current status of antisense RNA-mediated gene regulation in Listeria monocytogenes, Frontiers in Cellular and Infection Microbiology, 4, Article 135. https://doi.org/10.3389/fcimb.2014.00135

APA Citation style: Schultze, T., Izar, B., Qing, X., Mannala, G., & Hain, T. (2014). Current status of antisense RNA-mediated gene regulation in Listeria monocytogenes. Frontiers in Cellular and Infection Microbiology. 4, Article 135. https://doi.org/10.3389/fcimb.2014.00135