Journalartikel
Autorenliste: Cabrera-Fuentes, Hector A.; Ruiz-Meana, Marisol; Simsekyilmaz, Sakine; Kostin, Sawa; Inserte, Javier; Saffarzadeh, Mona; Galuska, Sebastian P.; Vijayan, Vijith; Barba, Ignasi; Barreto, Guillermo; Fischer, Silvia; Lochnit, Guenter; Ilinskaya, Olga N.; Baumgart-Vogt, Eveline; Boening, Andreas; Lecour, Sandrine; Hausenloy, Derek J.; Liehn, Elisa A.; Garcia-Dorado, David; Schlueter, Klaus-Dieter; Preissner, Klaus T.
Jahr der Veröffentlichung: 2014
Seiten: 1110-1119
Zeitschrift: Thrombosis and Haemostasis
Bandnummer: 112
Heftnummer: 6
ISSN: 0340-6245
eISSN: 2567-689X
Open Access Status: Green
DOI Link: https://doi.org/10.1160/TH14-08-0703
Verlag: Thieme Publishing
Abstract:
Despite optimal therapy, the morbidity and mortality of patients presenting with an acute myocardial infarction (MI) remain significant, and the initial mechanistic trigger of myocardial "ischaemia/reperfusion (I/R) injury" remains greatly unexplained. Here we show that factors released from the damaged cardiac tissue itself, in particular extracellular RNA (eRNA) and tumour-necrosis-factor alpha (TNF-alpha), may dictate I/R injury. In an experimental in vivo mouse model of myocardial I/R as well as in the isolated I/R Langendorff-perfused rat heart, cardiomyocyte death was induced by eRNA and TNF-alpha. Moreover, TNF-alpha promoted further eRNA release especially under hypoxia, feeding a vicious cell damaging cycle during I/R with the massive production of oxygen radicals, mitochondrial obstruction, decrease in antioxidant enzymes and decline of cardiomyocyte functions. The administration of RNase1 significantly decreased myocardial infarction 1 in both experimental models. This regimen allowed the reduction in; cytokine release, normalisation of antioxidant enzymes as well as; preservation of cardiac tissue. Thus, RNase1 administration provides a novel therapeutic regimen to interfere with the adverse eRNA-TNF-alpha interplay and significantly reduces or prevents the pathological out-come of ischaemic heart disease.
Zitierstile
Harvard-Zitierstil: Cabrera-Fuentes, H., Ruiz-Meana, M., Simsekyilmaz, S., Kostin, S., Inserte, J., Saffarzadeh, M., et al. (2014) RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-a in cardiac ischaemia/reperfusion injury, Thrombosis and Haemostasis, 112(6), pp. 1110-1119. https://doi.org/10.1160/TH14-08-0703
APA-Zitierstil: Cabrera-Fuentes, H., Ruiz-Meana, M., Simsekyilmaz, S., Kostin, S., Inserte, J., Saffarzadeh, M., Galuska, S., Vijayan, V., Barba, I., Barreto, G., Fischer, S., Lochnit, G., Ilinskaya, O., Baumgart-Vogt, E., Boening, A., Lecour, S., Hausenloy, D., Liehn, E., Garcia-Dorado, D., ...Preissner, K. (2014). RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-a in cardiac ischaemia/reperfusion injury. Thrombosis and Haemostasis. 112(6), 1110-1119. https://doi.org/10.1160/TH14-08-0703
Schlagwörter
CARDIOLOGY; CREATINE-KINASE; FACTOR-ALPHA; Inflammatory mediators; Ischaemic heart disease; ISCHEMIA-REPERFUSION INJURY; MYOCARDIAL ISCHEMIA/REPERFUSION; TROPONIN-T; VASCULAR SYSTEM
