Journal article

Publication year: 2014

Pages: 4678-4684

Journal: Acta Biomaterialia

Volume number: 10

Issue number: 11

ISSN: 1742-7061

eISSN: 1878-7568

DOI Link: https://doi.org/10.1016/j.actbio.2014.07.026

Publisher: Elsevier

Abstract: 
The current study investigated the mechanisms involved in the process of biophysical inhibition of pulmonary surfactant by polymeric nanoparticles (NP). The minimal surface tension of diverse synthetic surfactants was monitored in the presence of bare and surface-decorated (i.e. poloxamer 407) sub-100 nm poly(lactide) NP. Moreover, the influence of NP on surfactant composition (i.e. surfactant protein (SP) content) was studied. Dose-elevations of SP advanced the biophysical activity of the tested surfactant preparation. Surfactant-associated protein C supplemented phospholipid mixtures (PLM-C) were shown to be more susceptible to biophysical inactivation by bare NP than phospholipid mixture supplemented with surfactant protein B (PLM-B) and PLM-B/C. Surfactant function was hindered owing to a drastic depletion of the SP content upon contact with bare NP. By contrast, surface-modified NP were capable of circumventing unwanted surfactant inhibition. Surfactant constitution influences the extent of biophysical inhibition by polymeric NP. Steric shielding of the NP surface minimizes unwanted NP-surfactant interactions, which represents an option for the development of surfactant-compatible nanomedicines. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Harvard Citation style: Beck-Broichsitter, M., Ruppert, C., Schmehl, T., Guenther, A. and Seeger, W. (2014) Biophysical inhibition of pulmonary surfactant function by polymeric nanoparticles: Role of surfactant protein B and C, Acta Biomaterialia, 10(11), pp. 4678-4684. https://doi.org/10.1016/j.actbio.2014.07.026

APA Citation style: Beck-Broichsitter, M., Ruppert, C., Schmehl, T., Guenther, A., & Seeger, W. (2014). Biophysical inhibition of pulmonary surfactant function by polymeric nanoparticles: Role of surfactant protein B and C. Acta Biomaterialia. 10(11), 4678-4684. https://doi.org/10.1016/j.actbio.2014.07.026