Journal article

Influenza, a One Health paradigm-Novel therapeutic strategies to fight a zoonotic pathogen with pandemic potential


Authors list: Ludwig, Stephan; Zell, Roland; Schwemmle, Martin; Herold, Susanne

Publication year: 2014

Pages: 894-901

Journal: International Journal of Medical Microbiology

Volume number: 304

Issue number: 7

ISSN: 1438-4221

eISSN: 1618-0607

DOI Link: https://doi.org/10.1016/j.ijmm.2014.08.016

Publisher: Elsevier


Abstract: 
Influenza virus is a paradigm for a pathogen that frequently crosses the species barrier from animals to humans, causing severe disease in the human population. This ranges from frequent epidemics to occasional pandemic outbreaks with millions of death. All previous pandemics in humans were caused by animal viruses or virus reassortants carrying animal virus genes, underlining that the fight against influenza requires a One Health approach integrating human and veterinary medicine. Furthermore, the fundamental question of what enables a flu pathogen to jump from animals to humans can only be tackled in a transdisciplinary approach between virologists, immunologists and cell biologists. To address this need the German FluResearchNet was established as a first nationwide influenza research network that virtually integrates all national expertise in the field of influenza to unravel viral and host determinants of pathogenicity and species transmission and to explore novel avenues of antiviral intervention. Here we focus on the various novel anti-flu approaches that were developed as part of the FluResearchNet activities. (C) 2014 Elsevier GmbH. All rights reserved.



Citation Styles

Harvard Citation style: Ludwig, S., Zell, R., Schwemmle, M. and Herold, S. (2014) Influenza, a One Health paradigm-Novel therapeutic strategies to fight a zoonotic pathogen with pandemic potential, International Journal of Medical Microbiology, 304(7), pp. 894-901. https://doi.org/10.1016/j.ijmm.2014.08.016

APA Citation style: Ludwig, S., Zell, R., Schwemmle, M., & Herold, S. (2014). Influenza, a One Health paradigm-Novel therapeutic strategies to fight a zoonotic pathogen with pandemic potential. International Journal of Medical Microbiology. 304(7), 894-901. https://doi.org/10.1016/j.ijmm.2014.08.016



Keywords

ALVEOLAR EPITHELIAL-CELLS; ANTIVIRAL THERAPY; COLONY-STIMULATING FACTOR; GM-CSF PROTECTS; NEURAMINIDASE INHIBITORS; N-TERMINAL KINASE; One Health; Polymerase complex; SMALL-MOLECULE INHIBITORS; VIRUS PROPAGATION

Last updated on 2025-21-05 at 18:36