Journalartikel
Autorenliste: Abd El Rahman, Mohamed Y.; Rentzsch, Axel; Scherber, Philipp; Mebus, Siegrun; Miera, Oliver; Balling, Guenther; Boettler, Petra; Dubowy, Karl-Otto; Farahwaschy, Birgit; Hager, Alfred; Kreuder, Joachim; Peters, Brigitte; Berger, Felix; Schulze-Neick, Ingram; Abdul-Khaliq, Hashim
Jahr der Veröffentlichung: 2014
Seiten: 701-710
Zeitschrift: Clinical Research in Cardiology
Bandnummer: 103
Heftnummer: 9
ISSN: 1861-0684
eISSN: 1861-0692
DOI Link: https://doi.org/10.1007/s00392-014-0703-5
Verlag: Springer
The effect of bosentan on the ventricular and atrial performance in patients with Eisenmenger syndrome is unclear. In adult patients with Eisenmenger syndrome, we aimed to evaluate the midterm effect of bosentan on physical exercise, ventricular and atrial function, and pulmonary hemodynamics. Forty adult patients before and after 24 weeks bosentan therapy underwent 6 min walk test, two-dimensional speckle tracking echocardiography, plasma NT-proBNP measurement and cardiac catheterization. After 24 weeks, bosentan therapy an improvement was observed regarding the 6 min walk distance from a median (quartile 1-quartile 3) of 382.5 (312-430) to 450 (390-510) m (p = 0.0001), NT-proBNP from 527.5 (201-1,691.25) to 369 (179-1,246) pg/ml (p = 0.021), right ventricular mean longitudinal systolic strain from 18 (13-22) to 19 (14.5-25) % (p = 0.004), left ventricular mean longitudinal systolic strain from 16 (12-21) to 17 (16-22) % (p = 0.001), right atrial mean peak longitudinal strain from 26 (18-34) to 28 (22-34) % (p = 0.01) and right atrial mean peak contraction strain from 11 (8-16) to 13 (11-16) % (p = 0.005). The invasively obtained Qp:Qs and Rp:Rs did not significantly change under bosentan therapy. In adult patients with Eisenmenger syndrome, bosentan therapy improves ventricular and atrial functions resulting in enhancement of physical exercise and reduction in the NT-proBNP level, while the pulmonary vascular resistance does not change substantially.
Abstract:
Zitierstile
Harvard-Zitierstil: Abd El Rahman, M., Rentzsch, A., Scherber, P., Mebus, S., Miera, O., Balling, G., et al. (2014) Effect of bosentan therapy on ventricular and atrial function in adults with Eisenmenger syndrome. A prospective, multicenter study using conventional and Speckle tracking echocardiography, Clinical Research in Cardiology, 103(9), pp. 701-710. https://doi.org/10.1007/s00392-014-0703-5
APA-Zitierstil: Abd El Rahman, M., Rentzsch, A., Scherber, P., Mebus, S., Miera, O., Balling, G., Boettler, P., Dubowy, K., Farahwaschy, B., Hager, A., Kreuder, J., Peters, B., Berger, F., Schulze-Neick, I., & Abdul-Khaliq, H. (2014). Effect of bosentan therapy on ventricular and atrial function in adults with Eisenmenger syndrome. A prospective, multicenter study using conventional and Speckle tracking echocardiography. Clinical Research in Cardiology. 103(9), 701-710. https://doi.org/10.1007/s00392-014-0703-5
Schlagwörter
CARDIAC-FUNCTION; HEART-FAILURE; Myocardial contraction; Pulmonary arterial hypertension, echocardiography; remodeling; STRETCH
