Journal article
Authors list: Neumann, E.; Mueller-Ladner, U.; Frommer, K. W.
Publication year: 2014
Pages: 342-34+
Journal: Zeitschrift für Rheumatologie
Volume number: 73
Issue number: 4
ISSN: 0340-1855
eISSN: 1435-1250
DOI Link: https://doi.org/10.1007/s00393-013-1288-5
Publisher: Springer
Abstract:
A finely balanced relationship between bone resorption and bone formation is characteristic for a healthy bone metabolism. Osteoblasts are responsible for bone formation and osteoclasts for bone resorption. In general inflammatory and in particular chronic inflammatory processes influence osteoblast and osteoclast function directly or via indirect mechanisms. Bone metabolism can be influenced by the interaction of cytokines, hormones and growth factors with bone cells. A central factor involved in bone metabolism is the receptor activator of nuclear factor-kappa B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system, which is influenced by different inflammatory processes. Usually, (chronic) inflammation results in increased bone loss. The molecular mechanisms and pathophysiological pathways of bone metabolism under the influence of inflammation are summarized in this review.
Citation Styles
Harvard Citation style: Neumann, E., Mueller-Ladner, U. and Frommer, K. (2014) Inflammation and bone metabolism, Zeitschrift für Rheumatologie, 73(4), pp. 342-34+. https://doi.org/10.1007/s00393-013-1288-5
APA Citation style: Neumann, E., Mueller-Ladner, U., & Frommer, K. (2014). Inflammation and bone metabolism. Zeitschrift für Rheumatologie. 73(4), 342-34+. https://doi.org/10.1007/s00393-013-1288-5
Keywords
Bone resorption; infliximab; JOINT DAMAGE; METHOTREXATE; OSTEOBLASTS; OSTEOCLASTOGENESIS; OSTEOCLASTS; OSTEOPROTEGERIN; RANKL; Receptor activator of NF-kappa B ligand; RHEUMATOID-ARTHRITIS
