Journal article

Publication year: 2014

Pages: 504-513

Journal: Journal of Rehabilitation Medicine

Volume number: 46

Issue number: 6

ISSN: 1650-1977

eISSN: 1651-2081

Open access status: Gold

DOI Link: https://doi.org/10.2340/16501977-1817

Publisher: Medical Journals Sweden

Abstract: 

Objective: Evaluate changes in active and passive function with onabotulinumtoxinA + standard of care within goal-oriented rehabilitation programmes in adults with focal post-stroke spasticity.

Methods: Prospective, 24-week double-blind study with an open-label extension. Subjects were randomized to onabotulinumtoxinA + standard of care or placebo + standard of care, at baseline and at 12 weeks, if judged appropriate, with follow-up to 52 weeks. The primary endpoint was the number of patients achieving their principal active functional goal at 24 weeks (or 10 weeks after an optional second injection). Secondary endpoints included achievement of a different active or a passive goal at this timepoint.

Results: The intent-to-treat population comprised 273 patients. The proportion of patients achieving their principal active functional goal and secondary active functional goal with onabotulinumtoxinA + standard of care was not statistically different from placebo + standard of care. Significantly more patients achieved their secondary passive goal with onabotulinumtoxinA + standard of care (60.0%) vs. placebo + standard of care (38.6%) (odds ratio, 2.46; 95% confidence interval, 1.18-5.14) as well as higher Goal Attainment Scaling levels for upper limb and ankle flexor subgroups.

Conclusions: Addition of onabotulinumtoxinA to standard of care as part of goal-oriented rehabilitation in post-stroke spasticity patients significantly increased passive goal achievement and was associated with higher levels of active function.

Harvard Citation style: Ward, A., Wissel, J., Borg, J., Ertzgaard, P., Herrmann, C., Kulkarni, J., et al. (2014) FUNCTIONAL GOAL ACHIEVEMENT IN POST-STROKE SPASTICITY PATIENTS: THE BOTOX® ECONOMIC SPASTICITY TRIAL (BEST), Journal of Rehabilitation Medicine, 46(6), pp. 504-513. https://doi.org/10.2340/16501977-1817

APA Citation style: Ward, A., Wissel, J., Borg, J., Ertzgaard, P., Herrmann, C., Kulkarni, J., Lindgren, K., Reuter, I., Sakel, M., Satero, P., Sharma, S., Wein, T., Wright, N., & Fulford-Smith, A. (2014). FUNCTIONAL GOAL ACHIEVEMENT IN POST-STROKE SPASTICITY PATIENTS: THE BOTOX® ECONOMIC SPASTICITY TRIAL (BEST). Journal of Rehabilitation Medicine. 46(6), 504-513. https://doi.org/10.2340/16501977-1817