Journalartikel
Autorenliste: Weinandy, Franziska; Lorenz-Baath, Katrin; Korotkov, Vadim S.; Boettcher, Thomas; Sethi, Shneh; Chakraborty, Trinad; Sieber, Stephan A.
Jahr der Veröffentlichung: 2014
Seiten: 710-713
Zeitschrift: ChemMedChem
Bandnummer: 9
Heftnummer: 4
ISSN: 1860-7179
eISSN: 1860-7187
DOI Link: https://doi.org/10.1002/cmdc.201300325
Verlag: Wiley
Abstract:
Skin infections caused by Staphylococcus aureus are a major clinical concern, especially if they are caused by multi-resistant strains. In these cases, a spread into deeper soft tissues or the bloodstream results in life-threatening conditions that are difficult to treat by conventional antibiotics. Previous in vitro experiments with a small -lactone-based molecule demonstrated that antibiotic-sensitive and -resistant S.aureus strains are effectively disarmed in their virulence and corresponding pathogenicity. In this work, in vivo mouse studies show that this methodology is effective for the treatment of skin abscesses in mice. A single dose of the -lactone significantly decreased abscess size even when applied 6h post-infection. Although the molecule requires pharmacological optimization (improved stability, for example), this study emphasizes the potential value of antivirulence therapies.
Zitierstile
Harvard-Zitierstil: Weinandy, F., Lorenz-Baath, K., Korotkov, V., Boettcher, T., Sethi, S., Chakraborty, T., et al. (2014) A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice, ChemMedChem, 9(4), pp. 710-713. https://doi.org/10.1002/cmdc.201300325
APA-Zitierstil: Weinandy, F., Lorenz-Baath, K., Korotkov, V., Boettcher, T., Sethi, S., Chakraborty, T., & Sieber, S. (2014). A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice. ChemMedChem. 9(4), 710-713. https://doi.org/10.1002/cmdc.201300325
Schlagwörter
antivirulence drugs; caseinolytic proteaseP; CLPP PROTEASE; -lactones; mouse skin infection model; Staphylococcus aureus
