Journalartikel

Jahr der Veröffentlichung: 2014

Seiten: 163-169

Zeitschrift: Caries Research

Bandnummer: 48

Heftnummer: 2

ISSN: 0008-6568

eISSN: 1421-976X

DOI Link: https://doi.org/10.1159/000354679

Verlag: Karger Publishers

Abstract: 
The study investigated the erosion/abrasion-preventing potential of experimental NaF (1,400 ppm F-) and amine fluoride (AmF)/NaF/SnCl2/chitosan (1,400 ppm F-, 3,500 ppm Sn2+, 0.5% chitosan) toothpastes relative to placebo and SnF2 gel (970 ppm F-, 3,000 ppm Sn2+), and the impact of the demineralised dentine matrix on toothpaste effects. The study was a cyclic erosion/intervention experiment (10 days). Samples were stored in mineral salt solution either without or with collagenase (from Clostridium histolyticum type VII; 100 U/ml) for continuous removal of the organic matrix. To produce a comparable order of tissue loss, erosion was performed 6 x 30 s/day with 0.5% citric acid in the latter and 6 x 90 s/day with 1% citric acid in the former. Intervention was toothpaste slurry immersion (2 x 2 min/day); half of the samples were additionally brushed for 15 s within this time (brushing machine, load 200 g). Tissue loss was determined profilometrically (mean +/- SD; mu m). Tissue loss values (without/with brushing) for placebo, NaF, AmF/NaF/SnCl2/chitosan and SnF2 gel, respectively, were 11.6 +/- 3.1/12.2 +/- 2.5, 12.7 +/- 3.1/10.7 +/- 4.5, 8.7 +/- 2.1/9.7 +/- 2.1 and 8.8 +/- 1.8/10.9 +/- 1.8 in the presence of the organic matrix and 10.7 +/- 3.2/11.9 +/- 2.1, 8.2 +/- 4.0/10.1 +/- 4.1, 8.7 +/- 2.9/9.1 +/- 1.8 and 8.4 +/- 1.9/7.5 +/- 1.5 in the absence of the organic matrix. Relative to placebo, the NaF formulation had no significant effects; the AmF/NaF/SnCl2/chitosan formulation significantly reduced tissue loss between 20 and 25% except when applied without brushing in the absence of the organic matrix. The effects of the formulations were similar both in the presence and absence of the organic matrix. Sn2+/F--containing formulations have the potential to reduce erosion/abrasion even in the absence of demineralised collagen; seeking for more effective formulations is desirable. (c) 2014 S. Karger AG, Basel

Harvard-Zitierstil: Ganss, C., Klimek, J. and Schlueter, N. (2014) Erosion/Abrasion-Preventing Potential of NaF and F/Sn/Chitosan Toothpastes in Dentine and Impact of the Organic Matrix, Caries Research, 48(2), pp. 163-169. https://doi.org/10.1159/000354679

APA-Zitierstil: Ganss, C., Klimek, J., & Schlueter, N. (2014). Erosion/Abrasion-Preventing Potential of NaF and F/Sn/Chitosan Toothpastes in Dentine and Impact of the Organic Matrix. Caries Research. 48(2), 163-169. https://doi.org/10.1159/000354679