Journal article

Publication year: 2014

Pages: 81-88

Journal: Scandinavian Journal of Clinical and Laboratory Investigation

Volume number: 74

Issue number: 2

ISSN: 0036-5513

eISSN: 1502-7686

DOI Link: https://doi.org/10.3109/00365513.2013.860615

Publisher: Taylor and Francis Group

Abstract: 
Background. Contrast-induced acute kidney injury (CI-AKI) occurs in up to 13% of patients undergoing percutaneous coronary intervention (PCI). Neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for renal impairment. We investigated whether increased urinary NGAL concentrations were predictive of CI-AKI within 2 days after PCI or of a higher re-hospitalization rate within 9 months. Methods. Consecutive patients (n = 128), with stable coronary heart disease and eGFR > 30 mL/min/1.73 m 2, undergoing PCI were included. Venous serum samples for measurement of creatinine, blood urea nitrogen, and cystatin C and urine samples for NGAL measurement were collected 4 hours and 1 and 2 days after contrast medium application. Patients were followed over 9 months to determine clinical endpoints. Results. CI-AKI was observed in 14 patients (10.9%) after PCI. NGAL concentrations before PCI were significantly higher in patients with subsequent CI-AKI (19.8 ng/mL [14.4-35.8] vs. 11.6 ng/mL [5.6-28.2]; p = 0.04). There was no significant difference in NGAL concentrations 4 h after PCI between patients with and without CI-AKI. One day after PCI, NGAL concentrations were significant higher in patients developing CI-AKI (100.1 ng/mL [41.5-129.2] vs. 16.6 ng/mL [9.1-28.1]; p < 0.001). Compared to common biomarkers, NGAL best predicted CI-AKI (AUC 0.939 [95% CI 0.89-0.99; p < 0.001]). The re-hospitalization rate due to progressive renal insufficiency within 9 months was higher in the group with CI-AKI than the group without (4 [28.6%] vs. 4 [3.5%], p < 0.01). Conclusion. Urinary NGAL is a biomarker for predicting CI-AKI when measured 1 day after PCI.

Harvard Citation style: Liebetrau, C., Gaede, L., Doerr, O., Blumenstein, J., Rixe, J., Teichert, O., et al. (2014) Neutrophil gelatinase-associated lipocalin (NGAL) for the early detection of contrast-induced nephropathy after percutaneous coronary intervention, Scandinavian Journal of Clinical and Laboratory Investigation, 74(2), pp. 81-88. https://doi.org/10.3109/00365513.2013.860615

APA Citation style: Liebetrau, C., Gaede, L., Doerr, O., Blumenstein, J., Rixe, J., Teichert, O., Willmer, M., Weber, M., Rolf, A., Moellmann, H., Hamm, C., & Nef, H. (2014). Neutrophil gelatinase-associated lipocalin (NGAL) for the early detection of contrast-induced nephropathy after percutaneous coronary intervention. Scandinavian Journal of Clinical and Laboratory Investigation. 74(2), 81-88. https://doi.org/10.3109/00365513.2013.860615