Journalartikel

Jahr der Veröffentlichung: 2014

Seiten: 34-37

Zeitschrift: Clinica Chimica Acta

Bandnummer: 429

ISSN: 0009-8981

eISSN: 1873-3492

DOI Link: https://doi.org/10.1016/j.cca.2013.11.017

Verlag: Elsevier

Abstract: 

Background: N-terminal segment of B-type natriuretic peptide prohormone (NT-proBNP) is elevated in patients with acute myocardial infarction (AMI) thus providing both diagnostic information and prognostic information. The aim of the present study was to determine the time course of NT-proBNP release in patients undergoing transcoronary ablation of septal hypertrophy (TASH) a procedure mimicking AMI.

Methods: We analyzed the release kinetics of NT-proBNP in 18 consecutive patients with hypertrophic obstructive cardiomyopathy undergoing TASH. Serum samples were collected prior to and at 15, 30, 45, 60, 75, 90, and 105 min, and 2, 4, 8, and 24 h after TASH.

Results: NT-proBNP concentrations showed a continuous increase during the first 75 min with a significant percent change compared to baseline value already 15 min after TASH (105.6% [IQR 1022-112.7]; P < 0.001). All patients had a significant increase of NT-proBNP at 45 min (range of percent increase [min-max]: 103.5-137.2%; range of absolute increase [min-max]: 23.5-304.0 ng/L). NT-proBNP concentrations decreased below the baseline value until the 8th h after initiation of myocardial infarction.

Conclusion: NT-proBNP concentration increases immediately after induction of myocardial infarction proving early evidence of myocardial injury despite the decrease of the left ventricular wall stress due to the TASH related reduction of the left ventricular outflow gradient. (C) 2013 Elsevier B.V. All rights reserved.

Harvard-Zitierstil: Liebetrau, C., Gaede, L., Doerr, O., Troidl, C., Voss, S., Hoffmann, J., et al. (2014) Release kinetics of N-terminal pro-B-type natriuretic peptide in a clinical model of acute myocardial infarction, Clinica Chimica Acta, 429, pp. 34-37. https://doi.org/10.1016/j.cca.2013.11.017

APA-Zitierstil: Liebetrau, C., Gaede, L., Doerr, O., Troidl, C., Voss, S., Hoffmann, J., Paszko, A., Weber, M., Rolf, A., Hamm, C., Nef, H., & Moellmann, H. (2014). Release kinetics of N-terminal pro-B-type natriuretic peptide in a clinical model of acute myocardial infarction. Clinica Chimica Acta. 429, 34-37. https://doi.org/10.1016/j.cca.2013.11.017