Journal article
Authors list: Naehrlich, Lutz; Ballmann, Manfred; Davies, Jane; Derichs, Nico; Gonska, Tanja; Hjelte, Lena; van Konigsbruggen-Rietschel, Silke; Leal, Teresinha; Melotti, Paola; Middleton, Peter; Tuemmler, Burkhard; Vermeulen, Francois; Wilschanski, Michael
Publication year: 2014
Pages: 24-28
Journal: Journal of Cystic Fibrosis
Volume number: 13
Issue number: 1
ISSN: 1569-1993
eISSN: 1873-5010
DOI Link: https://doi.org/10.1016/j.jcf.2013.08.006
Publisher: Elsevier
Background: The role of nasal potential difference (NPD) measurement as a diagnostic test for cystic fibrosis (CF) is a subject of global controversy because of the lack of validation studies, clear reference values, and standardized protocols for diagnostic NPD. Methods: To determine diagnostic NPD frequency, protocols, interpretation, and rater agreement, we surveyed the 18 NPD centres of the European Cystic Fibrosis Society Diagnostic Network Working Group. Results: Fifteen centres reported performing 373 diagnostic NPDs in 2012. Most use the CFF-TDN-SCIP (67%) and the chloride-free + isoproterenol response of the side with the largest response (47%) as diagnostic criteria and use centre-specific reference ranges. Rater agreement for five NPD tracings in general was good, but poor in tracings with different responses between the two nostrils. Conclusions: NPD is frequently used as a diagnostic and research tool for CF. Performance is highly standardized, centre-specific reference ranges are established, and rater agreement in general is good. Centre-independent diagnostic criteria and reference ranges must be defined by multicentre validation studies to improve standardized interpretation for diagnostic use. (C) 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Abstract:
Citation Styles
Harvard Citation style: Naehrlich, L., Ballmann, M., Davies, J., Derichs, N., Gonska, T., Hjelte, L., et al. (2014) Nasal potential difference measurements in diagnosis of cystic fibrosis: An international survey, Journal of Cystic Fibrosis, 13(1), pp. 24-28. https://doi.org/10.1016/j.jcf.2013.08.006
APA Citation style: Naehrlich, L., Ballmann, M., Davies, J., Derichs, N., Gonska, T., Hjelte, L., van Konigsbruggen-Rietschel, S., Leal, T., Melotti, P., Middleton, P., Tuemmler, B., Vermeulen, F., & Wilschanski, M. (2014). Nasal potential difference measurements in diagnosis of cystic fibrosis: An international survey. Journal of Cystic Fibrosis. 13(1), 24-28. https://doi.org/10.1016/j.jcf.2013.08.006
Keywords
Cystic fibrosis; GUIDELINES; Nasal potential difference; PROTOCOLS; SWEAT TEST
