Journalartikel
Autorenliste: Visovatti, Scott H.; Distler, Oliver; Coghlan, J. Gerry; Denton, Christopher P.; Gruenig, Ekkehard; Bonderman, Diana; Mueller-Ladner, Ulf; Pope, Janet E.; Vonk, Madelon C.; Seibold, James R.; Torres-Martin, Juan-Vicente; Doelberg, Martin; Chadha-Boreham, Harbajan; Rosenberg, Daniel M.; McLaughlin, Vallerie V.; Khanna, Dinesh
Jahr der Veröffentlichung: 2014
Zeitschrift: Arthritis Research and Therapy
Bandnummer: 16
Heftnummer: 6
ISSN: 1478-6354
eISSN: 1478-6362
Open Access Status: Gold
DOI Link: https://doi.org/10.1186/s13075-014-0493-1
Verlag: BioMed Central
Introduction: Patients with mean pulmonary artery pressures (mPAP) of 21 to 24 mm Hg have a so-called borderline elevation of mPAP (BoPAP)-a condition thought to represent early-stage pulmonary arterial vasculopathy. Based on the DETECT study, this post-hoc analysis examined patient characteristics of systemic sclerosis (SSc) patients with normal mPAP, BoPAP and elevated mPAP, fulfilling pulmonary arterial hypertension (PAH) criteria. Methods: Adult patients with a duration of SSc more than 3 years, a diffusing capacity of the lung for carbon monoxide less than 60% predicted, and no previous diagnosis of any form of pulmonary hypertension (PH) underwent screening tests followed by right heart catheterization. Subjects were divided into three groups: normal mPAP, BoPAP, and PAH. Exploratory comparative and binary logistic regression analyses were performed for the BoPAP versus normal mPAP and PAH versus BoPAP groups. Results: Of 244 patients evaluated, 148 (60%) had normal mPAP, 36 (15%) had BoPAP, and 60 (25%) had definite PAH. Univariable logistic regression (ULR) showed the mean tricuspid regurgitation velocity in patients with BoPAP to be intermediate between normal mPAP and PAH. In the ULR analyses BoPAP versus normal mPAP and PAH versus BoPAP, the statistically significant predictors were, amongst others: demographic, clinical, pulmonary function, echocardiographic and hemodynamic variables. Conclusions: In this exploratory post-hoc analysis of the DETECT study population patients with BoPAP could be distinguished from patients with normal mPAP and PAH, and it appears that BoPAP may be an intermediate stage on the continuum between normal PA pressures and PAH.
Abstract:
Zitierstile
Harvard-Zitierstil: Visovatti, S., Distler, O., Coghlan, J., Denton, C., Gruenig, E., Bonderman, D., et al. (2014) Borderline pulmonary arterial pressure in systemic sclerosis patients: a post-hoc analysis of the DETECT study, Arthritis Research and Therapy, 16(6), Article 493. https://doi.org/10.1186/s13075-014-0493-1
APA-Zitierstil: Visovatti, S., Distler, O., Coghlan, J., Denton, C., Gruenig, E., Bonderman, D., Mueller-Ladner, U., Pope, J., Vonk, M., Seibold, J., Torres-Martin, J., Doelberg, M., Chadha-Boreham, H., Rosenberg, D., McLaughlin, V., & Khanna, D. (2014). Borderline pulmonary arterial pressure in systemic sclerosis patients: a post-hoc analysis of the DETECT study. Arthritis Research and Therapy. 16(6), Article 493. https://doi.org/10.1186/s13075-014-0493-1
Schlagwörter
BASE-LINE CHARACTERISTICS; COMMITTEE; DEATH; HIGH PREVALENCE; RECOMMENDATIONS
