Journal article

Publication year: 2014

Pages: 439-449

Journal: Acta Biomaterialia

Volume number: 10

Issue number: 1

ISSN: 1742-7061

eISSN: 1878-7568

DOI Link: https://doi.org/10.1016/j.actbio.2013.09.037

Publisher: Elsevier

Abstract: 
The prevention of implant-related infections is an important issue in medical research. The aim is to exploit the strong antimicrobial effect of silver nanoparticles (AgNP) to develop new antibacterial coatings for implants. However, there is still a serious lack of information on the influence of AgNP on bone metabolism. In the present study we have evaluated the influence of AgNP on cell stress, viability, proliferation and differentiation of primary human mesenchymal stem cells (MSC) and osteoblasts (OB). Finally, cellular uptake of the AgNP was examined. After 21 days impairment of cell viability of MSC and OB occurred at a concentration of 10 mu g/g of AgNP. Cytotoxicity and inhibition of proliferation was highly time and dose dependent. No influence on cell differentiation, but an increase in cell stress, was observed. Uptake of AgNP into MSC and OB could be confirmed. In summary, these results demonstrate AgNP-mediated cytotoxicity at higher concentrations. Therefore, a therapeutical window for the application of AgNP in medical products might exist. However, the antibacterial benefits and potential health risks of AgNP need to be weighed in further studies. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Harvard Citation style: Pauksch, L., Hartmann, S., Rohnke, M., Szalay, G., Alt, V., Schnettler, R., et al. (2014) Biocompatibility of silver nanoparticles and silver ions in primary human mesenchymal stem cells and osteoblasts, Acta Biomaterialia, 10(1), pp. 439-449. https://doi.org/10.1016/j.actbio.2013.09.037

APA Citation style: Pauksch, L., Hartmann, S., Rohnke, M., Szalay, G., Alt, V., Schnettler, R., & Lips, K. (2014). Biocompatibility of silver nanoparticles and silver ions in primary human mesenchymal stem cells and osteoblasts. Acta Biomaterialia. 10(1), 439-449. https://doi.org/10.1016/j.actbio.2013.09.037