Journal article

Publication year: 2013

Pages: L893-L905

Journal: American Journal of Physiology - Lung Cellular and Molecular Physiology

Volume number: 305

Issue number: 12

ISSN: 1040-0605

eISSN: 1522-1504

DOI Link: https://doi.org/10.1152/ajplung.00267.2013

Publisher: American Physiological Society

Abstract: 
In contrast to early lung development, a process exemplified by the branching of the developing airways, the later development of the immature lung remains very poorly understood. A key event in late lung development is secondary septation, in which secondary septa arise from primary septa, creating a greater number of alveoli of a smaller size, which dramatically expands the surface area over which gas exchange can take place. Secondary septation, together with architectural changes to the vascular structure of the lung that minimize the distance between the inspired air and the blood, are the objectives of late lung development. The process of late lung development is disturbed in bronchopulmonary dysplasia (BPD), a disease of prematurely born infants in which the structural development of the alveoli is blunted as a consequence of inflammation, volutrauma, and oxygen toxicity. This review aims to highlight notable recent developments in our understanding of late lung development and the pathogenesis of BPD.

Harvard Citation style: Madurga, A., Mizikova, I., Ruiz-Camp, J. and Morty, R. (2013) Recent advances in late lung development and the pathogenesis of bronchopulmonary dysplasia, American Journal of Physiology - Lung Cellular and Molecular Physiology, 305(12), pp. L893-L905. https://doi.org/10.1152/ajplung.00267.2013

APA Citation style: Madurga, A., Mizikova, I., Ruiz-Camp, J., & Morty, R. (2013). Recent advances in late lung development and the pathogenesis of bronchopulmonary dysplasia. American Journal of Physiology - Lung Cellular and Molecular Physiology. 305(12), L893-L905. https://doi.org/10.1152/ajplung.00267.2013