Journal article

Publication year: 2013

Pages: 255-258

Journal: Pediatric Obesity

Volume number: 8

Issue number: 4

ISSN: 2047-6310

eISSN: 2047-6302

DOI Link: https://doi.org/10.1111/j.2047-6310.2013.00163.x

Publisher: Wiley

Abstract: 

BackgroundStudies in animals and in man have demonstrated that excessive consumption of fructose can cause all components of the metabolic syndrome.

ObjectiveTo investigate the impact of a condition resulting in decreased absorption of fructose, on obesity.

MethodsIn a multicentre study, we analyzed a cohort of paediatric patients with suspected primary fructose malabsorption (FM). Patients with chronic intestinal diseases were excluded. The final cohort comprised 628 patients.

Results302 patients were diagnosed with primary FM (48.1%). The proportion of obese patients was lower among FM patients, compared to non-FM patients (2.3 vs. 6.1%, P=0.029). Logistic regression analysis with inclusion of various covariates showed that FM was negatively associated with obesity (OR 0.35, 95% CI [0.13; 0.97]). We discuss several mechanisms involving the metabolic, endocrine and gastrointestinal system.

ConclusionsOur data indicate that primary FM is negatively associated with childhood obesity.

Harvard Citation style: Disse, S., Buelow, A., Boedeker, R., Keller, K., Kim-Berger, H., Wudy, S., et al. (2013) Reduced prevalence of obesity in children with primary fructose malabsorption: a multicentre, retrospective cohort study, Pediatric Obesity, 8(4), pp. 255-258. https://doi.org/10.1111/j.2047-6310.2013.00163.x

APA Citation style: Disse, S., Buelow, A., Boedeker, R., Keller, K., Kim-Berger, H., Wudy, S., & Zimmer, K. (2013). Reduced prevalence of obesity in children with primary fructose malabsorption: a multicentre, retrospective cohort study. Pediatric Obesity. 8(4), 255-258. https://doi.org/10.1111/j.2047-6310.2013.00163.x