Journal article

Publication year: 2013

Pages: 805-810

Journal: Clinical Nutrition

Volume number: 32

Issue number: 5

ISSN: 0261-5614

eISSN: 1532-1983

Open access status: Bronze

DOI Link: https://doi.org/10.1016/j.clnu.2013.01.009

Publisher: Elsevier

Abstract: 

Background & aims: To determine the vitamin A status and appropriate supplementation dosage of cystic fibrosis (CF) patients who received vitamin A supplementation based on annual serum retinol measurements.

Methods: Vitamin A food intake, supplementation dosage, and serum retinol levels were obtained for 32 CF patients >4 years of age (4.3-27.3 years old) who had pancreatic insufficiency and mild-to-moderate lung disease (percent predicted of forced expiratory volume in 1 s > 40%). These measurements were compared with the dietary reference intake for healthy children and adults (D-A-CH dietary recommendations), US and German CF recommendations, and serum retinol concentrations from National Health and Nutrition Examination Survey (NHANES) data.

Results: Total vitamin A intake from food and supplementation was 315% +/-182% of D-A-CH recommendations, with 65% from supplements. The range of the prescribed vitamin A supplementation dosage was 0-20,000 IU/day (median 5500 IU), and it was consistent with CF recommendations in 28% of participants. A quarter of all patients did not need any vitamin A supplementation. The total vitamin A intake exceeded the recommended upper limit of intake in 69% of subjects. The mean (range) serum retinol was 38.6 mu g/dl (22.1-59.1 mu g/dl). All subjects had serum retinol levels above 20 mu g/dl and below 72 mu g/dl (95th percentile of NHANES reference range).

Conclusion: Individualized vitamin A supplementation of 0-20,000 IU/day based on annual serum retinol measurements may prevent deficiency and high serum retinal levels, but it may lead to vitamin A intake above the tolerable upper intake level. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Harvard Citation style: Brei, C., Simon, A., Krawinkel, M. and Naehrlich, L. (2013) Individualized vitamin A supplementation for patients with cystic fibrosis, Clinical Nutrition, 32(5), pp. 805-810. https://doi.org/10.1016/j.clnu.2013.01.009

APA Citation style: Brei, C., Simon, A., Krawinkel, M., & Naehrlich, L. (2013). Individualized vitamin A supplementation for patients with cystic fibrosis. Clinical Nutrition. 32(5), 805-810. https://doi.org/10.1016/j.clnu.2013.01.009