Journal article
Authors list: van den Hoogen, Frank; Khanna, Dinesh; Fransen, Jaap; Johnson, Sindhu R.; Baron, Murray; Tyndall, Alan; Matucci-Cerinic, Marco; Naden, Raymond P.; Medsger, Thomas A., Jr.; Carreira, Patricia E.; Riemekasten, Gabriela; Clements, Philip J.; Denton, Christopher P.; Distler, Oliver; Allanore, Yannick; Furst, Daniel E.; Gabrielli, Armando; Mayes, Maureen D.; van Laar, Jacob M.; Seibold, James R.; Czirjak, Laszlo; Steen, Virginia D.; Inanc, Murat; Kowal-Bielecka, Otylia; Mueller-Ladner, Ulf; Valentini, Gabriele; Veale, Douglas J.; Vonk, Madelon C.; Walker, Ulrich A.; Chung, Lorinda; Collier, David H.; Csuka, Mary Ellen; Fessler, Barri J.; Guiducci, Serena; Herrick, Ariane; Hsu, Vivien M.; Jimenez, Sergio; Kahaleh, Bashar; Merkel, Peter A.; Sierakowski, Stanislav; Silver, Richard M.; Simms, Robert W.; Varga, John; Pope, Janet E.
Publication year: 2013
Pages: 2737-2747
Journal: Arthritis & rheumatism
Volume number: 65
Issue number: 11
ISSN: 0004-3591
eISSN: 1529-0131
DOI Link: https://doi.org/10.1002/art.38098
Publisher: Wiley
ObjectiveThe 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present work, by a joint committee of the ACR and the European League Against Rheumatism (EULAR), was undertaken for the purpose of developing new classification criteria for SSc. MethodsUsing consensus methods, 23 candidate items were arranged in a multicriteria additive point system with a threshold to classify cases as SSc. The classification system was reduced by clustering items and simplifying weights. The system was tested by 1) determining specificity and sensitivity in SSc cases and controls with scleroderma-like disorders, and 2) validating against the combined view of a group of experts on a set of cases with or without SSc. ResultsIt was determined that skin thickening of the fingers extending proximal to the metacarpophalangeal joints is sufficient for the patient to be classified as having SSc; if that is not present, 7 additive items apply, with varying weights for each: skin thickening of the fingers, fingertip lesions, telangiectasia, abnormal nailfold capillaries, interstitial lung disease or pulmonary arterial hypertension, Raynaud's phenomenon, and SSc-related autoantibodies. Sensitivity and specificity in the validation sample were, respectively, 0.91 and 0.92 for the new classification criteria and 0.75 and 0.72 for the 1980 ACR classification criteria. All selected cases were classified in accordance with consensus-based expert opinion. All cases classified as SSc according to the 1980 ACR criteria were classified as SSc with the new criteria, and several additional cases were now considered to be SSc. ConclusionThe ACR/EULAR classification criteria for SSc performed better than the 1980 ACR criteria for SSc and should allow for more patients to be classified correctly as having the disease.
Abstract:
Citation Styles
Harvard Citation style: van den Hoogen, F., Khanna, D., Fransen, J., Johnson, S., Baron, M., Tyndall, A., et al. (2013) 2013 Classification Criteria for Systemic Sclerosis An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative, Arthritis & rheumatism, 65(11), pp. 2737-2747. https://doi.org/10.1002/art.38098
APA Citation style: van den Hoogen, F., Khanna, D., Fransen, J., Johnson, S., Baron, M., Tyndall, A., Matucci-Cerinic, M., Naden, R., Medsger, T., Carreira, P., Riemekasten, G., Clements, P., Denton, C., Distler, O., Allanore, Y., Furst, D., Gabrielli, A., Mayes, M., van Laar, J., ...Pope, J. (2013). 2013 Classification Criteria for Systemic Sclerosis An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative. Arthritis & rheumatism. 65(11), 2737-2747. https://doi.org/10.1002/art.38098
Keywords
AUTOANTIBODIES; CAPILLARY MICROSCOPY
