Journalartikel
Autorenliste: Liebetrau, Christoph; Doerr, Oliver; Baumgarten, Heike; Gaede, Luise; Szardien, Sebastian; Blumenstein, Johannes; Rolf, Andreas; Moellmann, Helge; Hamm, Christian; Walther, Thomas; Nef, Holger; Weber, Michael
Jahr der Veröffentlichung: 2013
Seiten: 392-399
Zeitschrift: Scandinavian Journal of Clinical and Laboratory Investigation
Bandnummer: 73
Heftnummer: 5
ISSN: 0036-5513
eISSN: 1502-7686
DOI Link: https://doi.org/10.3109/00365513.2013.787149
Verlag: Taylor and Francis Group
Abstract:
Background. Acute kidney injury (AKI) is a common complication after cardiac surgery. Neutrophil gelatinase-associated lipocalin (NGAL) may be an early biomarker for cardiac surgery-associated (CSA) AKI. We investigated whether increased urinary NGAL concentrations were predictive of AKI within 4 days after surgery and of mortality within 9 months. Methods. Consecutive patients (n = 141) undergoing major cardiac surgery were included. Creatinine, blood urea nitrogen, cystatin C and urinary NGAL were measured before, 4 hours and 4 days after extracorporeal circulation. Results. AKI was observed in 47 (33.3%) patients. The 4-hour urinary NGAL measurement was an independent predictor of stage 2 and 3 AKI (AUC 0.901; 95% CI 0.81-0.99). Patients with AKI had a higher 9-month mortality rate (19.1% vs. 3.2%; logrank 10.9; P = 0.001; HR 19.8; 95% CI 3.7-107.1). Urinary NGAL was not predictive of mortality within 9 months after surgery. Conclusion. Urinary NGAL is a biomarker for very early risk stratification of AKI after cardiac surgery and may be useful as a basis for early interventional strategies to prevent CSA-AKI.
Zitierstile
Harvard-Zitierstil: Liebetrau, C., Doerr, O., Baumgarten, H., Gaede, L., Szardien, S., Blumenstein, J., et al. (2013) Neutrophil gelatinase-associated lipocalin (NGAL) for the early detection of cardiac surgery associated acute kidney injury, Scandinavian Journal of Clinical and Laboratory Investigation, 73(5), pp. 392-399. https://doi.org/10.3109/00365513.2013.787149
APA-Zitierstil: Liebetrau, C., Doerr, O., Baumgarten, H., Gaede, L., Szardien, S., Blumenstein, J., Rolf, A., Moellmann, H., Hamm, C., Walther, T., Nef, H., & Weber, M. (2013). Neutrophil gelatinase-associated lipocalin (NGAL) for the early detection of cardiac surgery associated acute kidney injury. Scandinavian Journal of Clinical and Laboratory Investigation. 73(5), 392-399. https://doi.org/10.3109/00365513.2013.787149
Schlagwörter
Acute renal failure; ACUTE-RENAL-FAILURE; Extracorporeal circulation; LCN2; Major cardiac surgery; neutrophil gelatinase-associated lipocalin; URINARY
