Journal article

Publication year: 2013

Pages: 122-131

Journal: Research in Veterinary Science

Volume number: 94

Issue number: 1

ISSN: 0034-5288

eISSN: 1532-2661

DOI Link: https://doi.org/10.1016/j.rvsc.2012.07.029

Publisher: Elsevier

Abstract: 

The impact of systemic inflammatory response syndrome (SIRS) on all phases of coagulation is largely unknown in dogs.

Fifty-six healthy dogs (controls) and 25 diseased dogs were included. Based on physical and hematological examination, dogs were classified as "no-SIRS" (n = 7) or "SIRS" (n = 18). Evaluated coagulation variables included platelets, coagulation times, fibrinogen, antithrombin (AT), FVIII, protein C, protein S, activated protein C (APC)-ratio, calculated from aPTT with and without presence of APC, and kaolin-activated thrombelastography (TEG).

Overall, no-SIRS and SIRS were characterized by hypocoaguable state (P < 0.001 compared to controls) i.e., prolonged coagulation times, decreased AT (median 59 U/L and 89 U/L versus 126 U/L), and FVIII (median 19 U/L and 70 U/L versus 102 U/L). In no-SIRS and SIRS, APC-ratio was significantly lower than in the controls (median 1.1 and 2.0 versus 2.5, P < 0.01, P < 0.001).

Severe coagulopathies may be present in critically ill dogs without concurrent SIRS. APC-resistance is a frequent finding in severely diseased dogs. (C) 2012 Elsevier Ltd. All rights reserved.

Harvard Citation style: Bauer, N. and Moritz, A. (2013) Coagulation response in dogs with and without systemic inflammatory response syndrome - Preliminary results, Research in Veterinary Science, 94(1), pp. 122-131. https://doi.org/10.1016/j.rvsc.2012.07.029

APA Citation style: Bauer, N., & Moritz, A. (2013). Coagulation response in dogs with and without systemic inflammatory response syndrome - Preliminary results. Research in Veterinary Science. 94(1), 122-131. https://doi.org/10.1016/j.rvsc.2012.07.029