Journalartikel

Jahr der Veröffentlichung: 2013

Seiten: 879-886

Zeitschrift: Diabetes Care

Bandnummer: 36

Heftnummer: 4

ISSN: 0149-5992

eISSN: 1935-5548

Open Access Status: Hybrid

DOI Link: https://doi.org/10.2337/dc12-0807

Verlag: American Diabetes Association

Abstract: 

OBJECTIVE-The prevalence of cystic fibrosis-related diabetes (CFRD) has increased with improved life expectancy of patients. Clinical and care characteristics were compared with type 1 diabetes mellitus (T1DM) in a multicenter analysis of pediatric data.

RESEARCH DESIGN AND METHODS-Auxological and treatment data from 47,227 patients aged younger than 21 years with CFRD or T1DM in the German/Austrian Diabetes Prospective Documentation Initiative registry were analyzed by multivariable mixed regression modeling.

RESULTS-Diabetes onset (mean [interquartile range]) occurred later in individuals with CFRD (14.5 [11.8-16.3] years) than in individuals with T1DM (8.5 [4.9-11.8] years), with female preponderance in CFRD (59.1% vs. 47.5%; P < 0.01). CFRD patients had lower BMI standard deviation scores (-0.85 [-1.59 to -0.12] vs. +0.52 [-0.10 to +1.16]; P < 0.01) and lower HbA(1c) (6.87% vs. 7.97%; P < 0.01). Self-monitoring of blood glucose was more frequent in patients with T1DM(4.5 vs. 3.5; P < 0.01); 72% of CFRD patients received insulin. In insulin-treated patients, insulin dosage adjusted for age, sex, and diabetes duration differed significantly (T1DM: 0.79 IE per kilogram of body weight; CFRD: 0.83 IE per kilogram of body weight). Use of short-acting and long-acting insulin analogs was significantly more frequent in T1DM(47% vs. 39% and 37% vs. 28%; both P < 0.05). Metabolic control in CFRD patients without insulin was better compared with CFRD on insulin (HbA1c: 6.00 vs. 7.12; P < 0.01), but duration of disease was significantly shorter (0.8 years [0.1-2.4] compared with 2.4 years [0.6-4.6]). There was no significant difference for BMI standard deviations scores between CFRD patients with or without insulin treatment.

CONCLUSIONS-Pediatric patients with CFRD show clear auxological and metabolic differences from those with T1DM, with different treatment choices. Diabetes Care 36:879-886, 2013

Harvard-Zitierstil: Konrad, K., Thon, A., Fritsch, M., Froehlich-Reiterer, E., Lilienthal, E., Wudy, S., et al. (2013) Comparison of Cystic Fibrosis-Related Diabetes With Type 1 Diabetes Based on a German/Austrian Pediatric Diabetes Registry, Diabetes Care, 36(4), pp. 879-886. https://doi.org/10.2337/dc12-0807

APA-Zitierstil: Konrad, K., Thon, A., Fritsch, M., Froehlich-Reiterer, E., Lilienthal, E., Wudy, S., & Holl, R. (2013). Comparison of Cystic Fibrosis-Related Diabetes With Type 1 Diabetes Based on a German/Austrian Pediatric Diabetes Registry. Diabetes Care. 36(4), 879-886. https://doi.org/10.2337/dc12-0807